🇦🇪United Arab Emirates

Clinique vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Clinique and Sesderma are distinguished skincare brands that offer thoughtful solutions for diverse complexions. The American brand is widely loved for its moisturizers, serums, makeup removers, and eye products featuring hyaluronic acid, glycerin, and caffeine, making it best suited for dry sensitive and oily skin. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that best suit sensitive, hyperpigmented, and aging skin. While both emphasize targeted care, they differ in their foundational ingredients and regional heritage.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

en.wikipedia.orgelcompanies.combusinesswire.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Clinique and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Clinique vs Sesderma products

Questions and answers

Clinique or Sesderma: which is better?

Clinique is better for a wide range of everyday skincare routines because the products on this page list no fragrance and feature key ingredients like hyaluronic acid and caffeine that help hydrate and refresh the skin.

Dermatologic Therapy, 2022Skin Pharmacology and Physiology, 2013

What is the difference between Clinique and Sesderma?

Clinique features a large range of fragrance-free products with high fit levels for dry sensitive, oily, and sensitive skin, while Sesderma offers an Azelac RU Serum that contains fragrance and achieves a high fit for acne-prone skin, skin with dark spots, and combination skin.

Which is more affordable, Clinique or Sesderma?

The products on this page for Clinique have a high price point according to reviewers, while pricing information for Sesderma is not discussed here.

Which causes fewer breakouts, Clinique or Sesderma?

Clinique is unlikely to cause breakouts as a major issue for most users, though reviewers on this page sometimes note that the products on this page cause breakouts. Sesderma has limited data on this page regarding breakouts.

How do the founding years and countries of origin compare between Clinique and Sesderma?

Clinique was founded in the United States in 1968, while Sesderma was founded in Spain in 1989.

Which brand offers a wider variety of moisturizers and serums on this page, Clinique or Sesderma?

Clinique offers a much wider variety of moisturizers and serums on this page, whereas Sesderma lists only a single serum. The products on this page for Clinique include several targeted moisturizers and serums that help address various skin concerns.

How does the fragrance content differ between Clinique and Sesderma products listed on the page?

Clinique has no fragrance listed in any of the products on this page, whereas the Sesderma product includes fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play