Sesderma Azelac RU Liposomal Serum for combination skin
Azelaic Acid
Tranexamic Acid
Retinol
Niacin
4-ButylresorcinolHigh
- HighCombination Skin Fit
- HighEffectiveness
- HighSafety
A great choice for combination skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Highly suitable for your combination skin, azelaic acid and tranexamic acid regulate melanogenesis and provide anti-inflammatory action, addressing your main goal of evening skin tone. While these ingredients are beneficial for your skin type, the formula lacks targeted ingredients for oil control, which is a primary concern for your oily shine.
- The presence of 4-butylresorcinol and tranexamic acid effectively inhibits melanin production, offering excellent treatment for uneven skin tone.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.2Overall rating based on 100+ reviewsBased on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.
Highlights
Fast absorption Mostly Mentioned
- “absorbing very fast”
- “lightweight”
- “no oily residue”
- “sinks deep into skin”
Fades dark spots Often Mentioned
- “huge difference in pigmentation”
- “removed stains from face”
- “fades spots fast”
- “marks down to faint shadows”
Improves texture Often Mentioned
- “skin smooth and luminous”
- “leaves skin glowy”
- “soft and alive”
- “texture is better”
Acne control Sometimes Noted
- “kept breakouts at bay”
- “pimples heal faster”
- “good for acne”
- “prevented new imperfections”
Drying effect Sometimes Noted
- “cheeks felt tight”
- “can dry you out”
- “needs moisturizer”
- “slightly aggressive initially”
High price Rarely Noted
- “expensive”
- “small bottle”
- “pricey for the size”
Slow results Rarely Noted
- “didn't see any effect”
- “oldest marks still there”
- “not a magic wand”
- “took forever to work”
Sticky finish Rarely Noted
- “sticky at first”
- “slight tacky feel”
- “feels a bit sticky”
Sources: lovi.care, notino.ie, influenster.com, skinsort.com, perfumesclub.co.uk, makeup.uk, and more
Questions and answers
What makes Sesderma Azelac RU Liposomal Serum a great fit for combination skin?
This serum is a great fit for your combination skin because azelaic acid and tranexamic acid help even out your skin tone and calm redness safely without irritation. The 4-butylresorcinol and tranexamic acid effectively target and fade dark spots, making this formula wonderfully suited for your skin.
Which ingredients make this serum a good fit for combination skin?
This serum is a great fit for your combination skin because azelaic acid and tranexamic acid help even out your skin tone and calm inflammation. The formula also includes 4-butylresorcinol, retinol, and niacin, which work together to safely target dark spots and make your skin smooth without causing irritation.
What does Azelaic Acid do for combination skin?
Azelaic acid helps combination skin by calming redness, clearing breakouts, and fading dark spots while keeping the skin smooth. It is unlikely to irritate dry areas while working on oily spots. Combination skin of this type needs a balanced routine with gentle exfoliants and soothing hydrators.
Postepy Dermatologii I Alergologii, 2023Journal of Drugs in Dermatology, 2015
What does Tranexamic Acid do for combination skin?
Tranexamic acid helps fade dark spots and uneven areas across different parts of combination skin while improving overall brightness. This ingredient is generally well-tolerated and may help target unwanted pigment without causing widespread irritation.
Journal of Cosmetic Dermatology, 2024Journal of Cosmetic Science, 2020
Where does this serum go in a skincare routine for combination skin?
This serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it at night helps keep your skin safe around sun exposure, though some serums of this type can also be used in the morning or twice a day.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night. This formula is safe for your combination skin and is unlikely to cause irritation.
How often should I use this serum?
This treatment is typically used in the evening, following your cleansing step. It is unlikely to cause irritation on your combination skin and helps even out your skin tone over time.
Can this serum clog pores, cause breakouts or purging for combination skin?
This serum is unlikely to cause breakouts or clog pores on combination skin, as it is safe with no harsh ingredients that typically trigger irritation. Reviewers occasionally note a moderate drying effect, but it does not cause purging.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).
What the research says
Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.
Dermatology and Therapy, 2024Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.
Pharmaceutics, 2021Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.
Journal of the European Academy of Dermatology and Venereology, 2023Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4.
Journal of Research in Medical Sciences, 2023Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks.
Journal of Cosmetic Dermatology, 20164-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks.
Journal of the European Academy of Dermatology and Venereology, 2013Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications.
Molecular Pharmaceutics, 2017
Ingredients
Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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