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SK-II vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SK-II and Sesderma are distinguished skincare brands that offer luxurious moisturizers, potent serums, soothing masks, and refreshing toners to elevate daily regimens. The Japanese brand is known for its signature pitera ingredient, which suits dry and combination skin, while the Spanish brand is beloved for advanced serums and engineered formulas that suit sensitive, hyperpigmented, and aging skin types. Both lines feature standout solutions like the Genoptics Ultraura Essence and the Azelac RU Serum for acne-prone skin, alongside specialized treatments for dark spots, mature skin, pore area, roughness, and redness. Ultimately, regular use of their key formulations helps refine skin texture and promote a radiant complexion.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II stands out as a better choice among the products on this page, as it features fragrance-free options and achieves a High fit level for dry skin, combination skin, and dry sensitive skin.

What is the difference between SK-II and Sesderma?

SK-II is a Japanese brand founded in 1980 that features fragrance-free formulas centered around Pitera, with products on this page fitting dry, combination, and dry sensitive skin best. In comparison, Sesderma is a Spanish brand founded in 1989 whose Azelac RU Serum contains fragrance and works well for acne-prone skin and dark spots, though it is rated Low for dry skin types.

Which is more affordable, SK-II or Sesderma?

The products on this page do not list pricing details, so a comparison of affordability between SK-II and Sesderma cannot be made from this information.

Which causes fewer breakouts, SK-II or Sesderma?

For acne-prone skin, the products on this page by SK-II fit best, featuring Genoptics Ultraura Essence at a Superior level, while Sesderma's Azelac RU Serum reaches a High fit level.

Pharmaceutics, 2021

Which brand has been around longer, SK-II or Sesderma?

SK-II has been around longer, having been founded in Japan in 1980, whereas Sesderma was founded in Spain in 1989.

Do SK-II products contain fragrance, whereas Sesderma products do?

Every product from SK-II on this page lists no fragrance in its ingredients, whereas the Sesderma product on this page includes fragrance.

What is the key ingredient across SK-II products?

The key ingredient across the products on this page for SK-II is Pitera. Every product on this page for the brand lists no fragrance in its ingredients.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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