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SkinCeuticals vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SkinCeuticals and Sesderma are esteemed skincare brands that offer expertly formulated serums, moisturizers, cleansers, eye products, and meticulously engineered formulas. The American brand is deeply loved for incorporating glycerin, hyaluronic acid, and dimethicone, suiting dry and oily skin best by nourishing and balancing moisture levels effectively, with standout options like C E Ferulic for acne-prone skin, Sheer Physical UV Defense SPF 50 for skin with dark spots, and A.G.E. Advanced Eye for mature skin. Conversely, the Spanish brand is beloved for suiting sensitive, hyperpigmented, and aging skin types best, featuring standout products like Azelac RU Serum for acne-prone skin, where botanical extracts and active compounds work synergistically to refine skin texture and promote a radiant complexion. Through their distinct formulations, both brands differ as glycerin significantly increased skin hydration and restored barrier function, hyaluronic acid lengthened the duration of wrinkle reduction, and dimethicone significantly reduced incontinence-associated dermatitis prevalence.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Or茅al since 2005.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SkinCeuticals and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SkinCeuticals vs Sesderma products

SkinCeuticals vs Sesderma serums and treatments

Questions and answers

SkinCeuticals or Sesderma: which is better?

SkinCeuticals is the better option on this page, as it offers a vast selection of products with High and Superior Lovi fit levels for dry, oily, and combination skin, while Sesderma currently features only a single product.

What is the difference between SkinCeuticals and Sesderma?

SkinCeuticals is a US brand offering a large range of serums, cleansers, and moisturizers that fit dry, oily, and combination skin, whereas Sesderma is a Spanish brand featuring Azelac RU Serum on this page. SkinCeuticals products on this page are mostly fragrance-free, while the product from Sesderma includes fragrance.

Which is more affordable, SkinCeuticals or Sesderma?

SkinCeuticals is noted for a high price point among the products on this page, whereas affordability details for Sesderma are not specified here.

Which causes fewer breakouts, SkinCeuticals or Sesderma?

SkinCeuticals is a better fit for acne-prone skin because the products on this page include multiple targeted blemish serums and cleansers, whereas Sesderma only features one serum.

How many products from SkinCeuticals contain fragrance compared to Sesderma?

SkinCeuticals has 34 fragrance-free products and 3 products with fragrance, whereas Sesderma has none without fragrance and 1 product with fragrance.

When were SkinCeuticals and Sesderma founded and which countries are they from?

SkinCeuticals was founded in the United States in 1994, while Sesderma was founded in Spain in 1989.

Which SkinCeuticals product achieves a Superior fit level for dry skin and dry sensitive skin?

Triple Lipid Restore 2:4:2 is a SkinCeuticals moisturizer that achieves a Superior fit level for both dry skin and dry sensitive skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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