Sesderma vs FRE
Sesderma and FRE are distinct skincare brands offering advanced serums and nourishing formulas. The Spanish enterprise founded in 1989 is known for its meticulously engineered formulas, including the Azelac RU Serum, while the second brand is celebrated for its gentle and effective compositions, such as the Argan Oil. Sesderma suits sensitive, hyperpigmented, and aging skin types best, whereas FRE suits acne-prone skin best. The brands differ through their botanical extracts and active compounds that refine skin texture versus thoughtful formulations that gently balance and support the complexion.
Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.
skinexpert.sesderma.comsesderma.com
This page compares some of the most popular Sesderma and FRE products; for every product of both brands, with a fit score for your own skin, use the Lovi app.
Questions and answers
Sesderma or FRE: which is better?
Neither brand is universally better, as Sesderma achieves a High Lovi fit for acne-prone skin and dark spots with its Azelac RU Serum, while FRE reaches a High Lovi fit for dry sensitive skin with its Argan Oil. FRE also has no fragrance in its products on this page, whereas the Sesderma serum contains fragrance.
Pharmaceutics, 2021International Journal of Nanomedicine, 2014
What is the difference between Sesderma and FRE?
Sesderma offers Azelac RU Serum, which has High Lovi fit for acne-prone skin, dark spots, and combination skin, but contains fragrance. FRE offers Argan Oil, which has High Lovi fit for dry sensitive skin and no added fragrance.
Pharmaceutics, 2021International Journal of Nanomedicine, 2014
Which is more affordable, Sesderma or FRE?
Neither Sesderma nor FRE lists pricing details or affordability comparisons for the products on this page.
Which causes fewer breakouts, Sesderma or FRE?
FRE and Sesderma both offer products on this page that may help with breakouts, such as FRE Argan Oil and Sesderma Azelac RU Serum. Lovi rates Azelac RU Serum as having a High fit for acne-prone skin, while Argan Oil receives an Average fit for the same skin type.
Pharmaceutics, 2021International Journal of Nanomedicine, 2014
Which brand was founded earlier, Sesderma or FRE?
Sesderma was founded earlier in 1989 in Spain, whereas FRE was founded in 2016.
Do both Sesderma and FRE offer products suitable for dry sensitive skin?
Yes, FRE offers Argan Oil which has a High Lovi fit for dry sensitive skin, whereas Sesderma's Azelac RU Serum has a Low fit for this skin type. FRE's product also lists no fragrance.
Which brand includes fragrance in its products listed on this page?
Sesderma includes fragrance in its products on this page, specifically in the Azelac RU Serum. In contrast, every FRE product listed on this page is formulated without fragrance.
Research behind their key ingredients
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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