Sesderma vs Natura Bissé
Sesderma and Natura Bissé are renowned Spanish skincare houses that offer advanced formulas designed to restore balance and vitality. The former is celebrated for its precise serums featuring botanical extracts and active compounds, while the latter is beloved for its luxurious moisturizers with rich nourishing properties. Both suit sensitive skin, though the first brand is especially ideal for hyperpigmented and aging concerns, and the second excels for mature and dry complexions. Ultimately, they differ through their distinct product types and targeted ingredients, with the Azelac RU Serum addressing acne-prone needs alongside the Diamond Extreme.
Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.
skinexpert.sesderma.comsesderma.com
Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..
This page compares some of the most popular Sesderma and Natura Bissé products; for every product of both brands, with a fit score for your own skin, use the Lovi app.
Questions and answers
Sesderma or Natura Bissé: which is better?
Natura Bissé has a Superior fit for mature skin, whereas Sesderma has a High fit for acne-prone skin and skin with dark spots.
What is the difference between Sesderma and Natura Bissé?
Natura Bissé offers Diamond Extreme, which Lovi rates as Superior for mature skin, whereas Sesderma offers Azelac RU Serum, which Lovi rates as High for acne-prone and dark spots.
Which is more affordable, Sesderma or Natura Bissé?
The page facts do not provide pricing information for either Sesderma or Natura Bissé, so it is not possible to determine which brand is more affordable.
Which causes fewer breakouts, Sesderma or Natura Bissé?
For acne-prone skin, Lovi rates both Sesderma and Natura Bissé as having an Average fit.
Which brand was founded earlier, Sesderma or Natura Bissé?
Natura Bisse was founded earlier in 1979, while Sesderma was founded later in 1989.
How does the Lovi fit level for mature skin compare between Sesderma's Azelac RU Serum and Natura Bissé's Diamond Extreme?
For mature skin, Natura Bissé Diamond Extreme has a Superior Lovi fit level, whereas Sesderma Azelac RU Serum has an Average Lovi fit level.
Do both Sesderma and Natura Bissé products on this page contain fragrance?
Yes, both Sesderma and Natura Bissé products on this page contain fragrance.
Research behind their key ingredients
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.
