Sesderma and Trilogy are two skincare collections known for distinct botanical extracts, active compounds, and high-performing formulas. Sesderma is beloved for its advanced serums that suit sensitive, hyperpigmented, and aging skin types best, while the brand is also recognized for the Azelac RU Serum designed for acne-prone skin. Trilogy is deeply loved for its thoughtful moisturizers and gentle cleansers, which suit dry, balanced, and sensitive skin types best alongside standout options like the Vitamin C Ceramide Night Cream, Rosehip Cream Cleanser, and Line Smoothing Day Cream. While both utilize botanical extracts and active compounds to refine skin texture and promote a radiant complexion, they differ in their signature product types and their tailored approaches to specific skin concerns.
Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.
This page compares some of the most popular Sesderma and Trilogy products; for every product of both brands, with a fit score for your own skin, use the Lovi app.
Trilogy offers more hydration and brightening options for a wider range of skin types, while Sesderma features a targeted serum. Lovi gives Trilogy high fit for dry and mature skin types with its creams.
What is the difference between Sesderma and Trilogy?
Sesderma offers a single serum on this page with High fit for acne-prone, dark-spot, and combination skin, while Trilogy provides a wider range of cleansers and moisturizers featuring high hydration for dry, sensitive, and mature skin types. Reviewers mostly mention hydrating and brightening benefits for Trilogy, alongside some product performance and formulation complaints.
Which is more affordable, Sesderma or Trilogy?
Neither Sesderma nor Trilogy shows pricing details on this page, so affordability cannot be compared.
Which causes fewer breakouts, Sesderma or Trilogy?
Trilogy has products on this page that are a High fit for sensitive skin, whereas Sesderma's serum has an Average fit for sensitive skin, and neither brand features products formulated solely for acne-prone skin.
Which brand has products with a High Lovi fit level for dry skin?
Trilogy has products on this page with a High Lovi fit level for dry skin, including Rosehip Cream Cleanser, Vitamin C Ceramide Night Cream, and Line Smoothing Day Cream. Sesderma's Azelac RU Serum has a Low fit level for dry skin.
How does the fragrance content compare between Sesderma and Trilogy products on this page?
Sesderma has fragrance in all of the products on this page, whereas Trilogy has fragrance in two out of three of its products.
Which company was founded earlier, Sesderma or Trilogy?
Sesderma was founded earlier in 1989 in Spain, whereas Trilogy was founded later in 2002.
Ceramide iii · Skin Pharmacology and Physiology, 2026
Behind this comparison
Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
