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Neutrogena vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Neutrogena and Sesderma are well-established skincare brands originating from America and Spain respectively. The American brand is universally loved for its reliable moisturizers, sunscreens, cleansers, and toners formulated with glycerin, hyaluronic acid, and dimethicone, while the Spanish brand is beloved for its advanced serums and meticulously engineered formulas featuring botanical extracts and active compounds. Neutrogena suits mature skin and combination skin best, whereas Sesderma suits sensitive, hyperpigmented, and aging skin types best. They differ primarily in their formulation approaches and regional heritage, offering distinct solutions like the Daily Facial Moisturizer and the Azelac RU Serum to address particular concerns.

Neutrogena is an American skincare brand founded in 1930 and owned by Kimberly-Clark Corporation since 2026.

investor.kimberly-clark.comen.wikipedia.orginvestors.kenvue.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Neutrogena and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Neutrogena vs Sesderma products

Questions and answers

Neutrogena or Sesderma: which is better?

Neutrogena offers a much wider variety of products on this page across multiple skin types, whereas Sesderma is represented by only a single serum. Reviewers frequently note that Neutrogena's moisturizers are deeply hydrating, lightweight, and non-greasy.

What is the difference between Neutrogena and Sesderma?

Neutrogena offers a large range of 39 products featuring key ingredients like hyaluronic acid and retinol, whereas Sesderma is represented by a single product on this page called Azelac RU Serum. Neutrogena products on this page achieve High to Superior fit levels for mature and combination skin, while Azelac RU Serum is rated High for acne-prone skin and skin with dark spots.

The Journal of Investigative Dermatology, 2000Journal of Pharmacy & Pharmaceutical Sciences, 2015

Which is more affordable, Neutrogena or Sesderma?

The products on this page for Neutrogena and Sesderma do not list pricing information, so affordability cannot be compared here.

Which causes fewer breakouts, Neutrogena or Sesderma?

Neutrogena offers multiple products on this page with a Superior or High Lovi fit for acne-prone skin, such as the Ultra Gentle Daily Cleanser, whereas Sesderma only features Azelac RU Serum.

Between Neutrogena and Sesderma, which brand was founded earlier and in which countries?

Neutrogena was founded earlier in 1930 in the United States, while Sesderma was founded in 1989 in Spain.

How many products from Neutrogena contain fragrance compared to Sesderma?

Neutrogena has 35 products on this page that list no fragrance and 4 products with fragrance, while Sesderma has 1 product on this page and it contains fragrance.

Which key skincare ingredients are shared across the products of these two brands?

Neutrogena uses key ingredients like glycerin, hyaluronic acid, dimethicone, avobenzone, vitamin C, salicylic acid, retinol, and homosalate across the products on this page, while Sesderma features Azelac RU Serum. Neither brand shares any common active ingredients listed on this page.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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