Kiehl's Vital Skin-Strengthening Super Serum for mature skin

How to apply

Questions and answers

What the research says

• A mixture of Panax ginseng and Crataegus pinnatifida prevented skin aging by improving procollagen type I expression, diminishing matrix metalloproteinase-1 secretion, reducing skin roughness and photodamage scores, and decreasing loss of skin moisture in human dermal fibroblasts and healthy human skin.

  Journal of Ginseng Research, 2017

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Aqueous Schisandra chinensis extracts promoted keratinocyte growth, demonstrated high antioxidant potential and strong tyrosinase inhibitory activity, and reduced skin irritation when added to body wash gel formulations.

  Molecules, 2022

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels.

  International Journal of Molecular Sciences, 2018

• Omija essential oil obtained by supercritical fluid extraction significantly reduced UV-B-induced ROS production in HaCaT keratinocytes and inhibited NO production in lipopolysaccharide-induced RAW 264.7 macrophages by suppressing iNOS expression and the NF-kappaB pathway.

  Foods, 2021

• Schisandrin B protected human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage by reducing cell death, oxidative stress, and DNA damage while enhancing antioxidant enzyme expression through the Nrf2 signaling pathway.

  International Journal of Molecular Medicine, 2018

• Capryloyl salicylic acid peel reduced fine lines, wrinkles, and hyperpigmentation comparably to glycolic acid peel in 44 female volunteers, with no statistically significant differences between the two treatments.

  Journal of Cosmetic Dermatology, 2008

• Combining a salicylic acid and lipohydroxy acid facial serum and mask improved closed comedones and acne severity significantly more than serum alone in adults with acne over 8 weeks, with no adverse reactions reported.

  Journal of Cosmetic Dermatology, 2023

• Parity was demonstrated between an OTC BPO 5.5% formulation with lipohydroxy acid and tretinoin cream 0.025% versus prescription clindamycin 1%-BPO 5% gel and tretinoin cream 0.025% in participants with mild to moderate acne vulgaris at 12 weeks.

  Cutis, 2012

Ingredients

Water, Dimethicone, Glycerin, Alcohol Denat, Hamamelis Virginiana Water Witch Hazel Water, Propanediol, Phenoxyethanol, Tocopherol, Ammonium Polyacryloyldimethyl Taurate, Schisandra Chinensis Fruit Extract, Capryloyl Salicylic Acid, Caprylyl Glycol, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Panax Ginseng Root Extract, Sodium Acetylated Hyaluronate, Peg-20 Methyl Glucose Sesquistearate, Disodium Edta, Ocimum Sanctum Leaf Extract, Citrus Aurantium Dulcis Orange Peel Oil, Limonene, Adenosine, Sodium Hydroxide, Methyldihydrojasmonate, Citric Acid, Eugenol, Sodium Benzoate, Pelargonium Graveolens Oil Flower, Citral, Potassium Sorbate, Lavandula Angustifolia Lavender Oil, Cymbopogon Schoenanthus Oil, Citronellol, Linalool, Geraniol, Rosmarinus Officinalis Rosemary Oil Leaf

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.