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SkinCeuticals vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

SkinCeuticals and Sesderma are distinguished skincare houses offering sophisticated serums, moisturizers, cleansers, and eye treatments. The American brand is loved for formulations featuring glycerin, hyaluronic acid, and dimethicone that suit dry and mature skin best, while the Spanish brand is beloved for advanced serums and engineered formulas that suit sensitive, hyperpigmented, and aging skin types. Both brands provide standout solutions for particular concerns, such as acne-prone skin, dark spots, and mature skin. They primarily differ in their geographic origin, founding years, ownership, and specific ingredient profiles, with the former utilizing classic hydrators and the latter employing botanical extracts and active compounds.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Oréal since 2005.

loreal.comskinceuticals-za.compitchbook.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SkinCeuticals and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SkinCeuticals vs Sesderma products

SkinCeuticals vs Sesderma serums and treatments

Questions and answers

SkinCeuticals or Sesderma: which is better?

SkinCeuticals is a better choice for most shoppers on this page because it offers a much wider range of products tailored to dry, mature, and sensitive skin. Lovi rates SkinCeuticals as having superior or high fit levels across many of its moisturizers and serums, whereas Sesderma currently features only a single product on this page.

What is the difference between SkinCeuticals and Sesderma?

SkinCeuticals is a US brand offering a large variety of serums, moisturizers, and cleansers best fitted for dry, mature, and dry sensitive skin, while Sesderma is a Spanish brand represented on this page by just one serum, Azelac RU Serum. SkinCeuticals products on this page are mostly fragrance-free, whereas Sesderma's product includes fragrance.

Which is more affordable, SkinCeuticals or Sesderma?

SkinCeuticals is noted for having a high price point among the products on this page. Sesderma is not discussed regarding affordability on this page.

Which causes fewer breakouts, SkinCeuticals or Sesderma?

SkinCeuticals includes several serums and cleansers that help control oil and breakouts, whereas the products on this page for Sesderma do not focus on acne control.

Between SkinCeuticals and Sesderma, which brand was founded earlier and in which country?

Sesderma was founded earlier in 1989 in Spain, whereas SkinCeuticals was founded in 1994 in the United States.

How do the fragrance profiles of SkinCeuticals and Sesderma products compare based on the listed items?

SkinCeuticals products on this page mostly lack added fragrance, with only a few items containing it, whereas all listed Sesderma products feature fragrance.

Which SkinCeuticals products have a Superior Lovi fit level for mature skin?

SkinCeuticals has a Superior Lovi fit level for mature skin with its C E Ferulic serum, Triple Lipid Restore 2:4:2 moisturizer, and A.G.E. Advanced Eye eye product.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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