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SkinCeuticals vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SkinCeuticals and Sesderma are esteemed skincare brands originating from America and Spain, respectively. The American brand is known for its targeted serums, nourishing moisturizers, gentle cleansers, and soothing eye products formulated with glycerin, hyaluronic acid, and dimethicone, which suit oily and dry sensitive skin best. Conversely, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas that suit sensitive, hyperpigmented, and aging skin types best. These two skincare lines differ primarily in their specific ingredient applications and targeted complexions, offering distinct paths to restored skin health.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Or茅al since 2005.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SkinCeuticals and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SkinCeuticals vs Sesderma products

SkinCeuticals vs Sesderma serums and treatments

Questions and answers

SkinCeuticals or Sesderma: which is better?

SkinCeuticals is the better choice on this page because it offers a wide variety of products with high fit levels across multiple skin types, whereas Sesderma only features a single product.

What is the difference between SkinCeuticals and Sesderma?

SkinCeuticals offers a large range of 37 specialized products that fit oily skin, dry sensitive skin, and oily acne-prone skin, while Sesderma features only 1 product on this page called Azelac RU Serum.

Which is more affordable, SkinCeuticals or Sesderma?

The page does not provide pricing information for either SkinCeuticals or Sesderma, so affordability cannot be compared here.

Which causes fewer breakouts, SkinCeuticals or Sesderma?

SkinCeuticals fits acne-prone skin well across many products on this page, whereas Sesderma has only one acne-friendly serum listed. SkinCeuticals offers specialized options like Blemish + Age Defense that help control oil and breakouts.

How does the founding year and country of origin compare between SkinCeuticals and Sesderma?

SkinCeuticals was founded in the United States in 1994, whereas Sesderma was founded in Spain in 1989.

Which products containing fragrance are available from SkinCeuticals versus Sesderma?

SkinCeuticals has three products containing fragrance on this page, which are Phyto Corrective Gel, A.G.E. Interrupter, and Phyto Corrective Masque. In comparison, Sesderma offers one product on this page, Azelac RU Serum, and it also contains fragrance.

How do the Lovi fit levels for dry skin compare between SkinCeuticals' P-TOX and Sesderma's Azelac RU Serum?

SkinCeuticals' P-TOX has a High Lovi fit level for dry skin, whereas Sesderma's Azelac RU Serum has a Low fit level for dry skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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