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SkinCeuticals vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SkinCeuticals and Sesderma are esteemed skincare brands that offer advanced serums, nourishing moisturizers, gentle cleansers, and soothing eye products. The American brand is loved for its glycerin, hyaluronic acid, and dimethicone formulations that suit dry skin and dry sensitive skin best, while the Spanish brand is beloved for its meticulous engineering that suits sensitive, hyperpigmented, and aging skin types best. Both brands differ in their specific botanical extracts, active compounds, and restorative elements designed to target concerns like acne, dark spots, and mature skin.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Or茅al since 2005.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

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This page compares some of the most popular SkinCeuticals and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SkinCeuticals vs Sesderma products

SkinCeuticals vs Sesderma serums and treatments

Questions and answers

SkinCeuticals or Sesderma: which is better?

SkinCeuticals is a High fit for dry, dry sensitive, and sensitive skin types based on the products on this page, whereas Sesderma only has one product featured.

What is the difference between SkinCeuticals and Sesderma?

SkinCeuticals is an American brand founded in 1994, offering a large selection of products on this page that fit dry, dry sensitive, and sensitive skin, whereas Sesderma is a Spanish brand founded in 1989 with only one product listed here. The products on this page from SkinCeuticals mostly feature fragrance-free formulas, while Sesderma's single product includes fragrance.

Which is more affordable, SkinCeuticals or Sesderma?

SkinCeuticals is a US brand with a high price point noted by reviewers, while Sesderma is founded in Spain.

Which causes fewer breakouts, SkinCeuticals or Sesderma?

SkinCeuticals has many products on this page with a high fit for acne-prone skin, such as Blemish + Age Defense, while Sesderma has only one featured product.

How many products from SkinCeuticals contain fragrance compared to Sesderma?

SkinCeuticals has 34 fragrance-free products and 3 products with fragrance among the products on this page, while Sesderma has 1 product on the page and it contains fragrance.

When were SkinCeuticals and Sesderma founded and which countries are they from?

SkinCeuticals was founded in the United States in 1994, while Sesderma was founded in Spain in 1989.

Which SkinCeuticals products have a Superior fit level for dry skin?

SkinCeuticals Triple Lipid Restore 2:4:2 and Hydrating B5 Masque have a Superior Lovi fit level for dry skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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