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SkinCeuticals vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

SkinCeuticals and Sesderma are esteemed skincare brands that offer advanced serums, nourishing moisturizers, gentle cleansers, and soothing eye products. The American brand is loved for its glycerin, hyaluronic acid, and dimethicone formulations that suit dry skin and dry sensitive skin best, while the Spanish brand is beloved for its meticulous engineering that suits sensitive, hyperpigmented, and aging skin types best. Both brands differ in their specific botanical extracts, active compounds, and restorative elements designed to target concerns like acne, dark spots, and mature skin.

SkinCeuticals is an American skincare brand founded in 1994 and owned by L'Oréal since 2005.

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Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SkinCeuticals and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SkinCeuticals vs Sesderma products

SkinCeuticals vs Sesderma serums and treatments

Questions and answers

SkinCeuticals or Sesderma: which is better?

SkinCeuticals is a better fit overall for most users because the products on this page cover a wide range of skin types with High and Superior fit levels, whereas Sesderma currently features only a single serum.

What is the difference between SkinCeuticals and Sesderma?

SkinCeuticals is a US brand offering a wide range of texture-improving and hydrating products, whereas Sesderma is a Spanish brand with only one serum featured on this page. SkinCeuticals fits best for dry, dry sensitive, and oily skin, while the products on this page help address concerns like skin aging and dark spots.

Which is more affordable, SkinCeuticals or Sesderma?

The products on this page for SkinCeuticals are noted by reviewers for having a high price point, while affordability information for Sesderma is not available.

Which causes fewer breakouts, SkinCeuticals or Sesderma?

SkinCeuticals offers multiple products on this page that help control acne, such as Blemish + Age Defense, while the products on this page from Sesderma are limited to Azelac RU Serum.

How do the founding years and countries of origin compare between SkinCeuticals and Sesderma?

SkinCeuticals was founded in the United States in 1994, whereas Sesderma was founded in Spain in 1989.

Which SkinCeuticals products contain fragrance compared to Sesderma's Azelac RU Serum?

Among the products on this page, SkinCeuticals includes fragrance in Phyto Corrective Gel, A.G.E. Interrupter, and Phyto Corrective Masque, while Sesderma's Azelac RU Serum also contains fragrance.

What are the key ingredients featured across SkinCeuticals products?

SkinCeuticals features key ingredients such as glycerin, hyaluronic acid, dimethicone, glycolic acid, salicylic acid, vitamin C, ferulic acid, and aloe vera across the products on this page.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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