Anua NANO RETINOL™ 0.3% + NIACIN RENEWING SERUM for mature skin
Retinol
Niacinamide
Hyaluronic Acid
Panthenol
AllantoinHigh
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers high suitability for normal skin as niacinamide and hyaluronic acid provide humectant action and barrier repair, complementing your goal of addressing wrinkles and fine lines.
- Retinol and adenosine in moderate concentrations further promote skin renewal, smoothing texture and minimizing fine lines for effective results.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.7Overall rating based on 200+ reviewsUsers find this serum to be an excellent gentle introduction to retinol, effectively smoothing skin texture and refining pores with minimal irritation. While improvements to fine lines and blackheads require consistent use, the formula hydrates and plumps the skin, leaving it glowing and moisturized.
Highlights
Gentle & non-irritating Often Mentioned
- “great for beginners”
- “no harsh peeling”
- “mild formula”
- “zero sensitivity”
Improves texture & pores Often Mentioned
- “pores visibly tightened”
- “glass skin texture”
- “smoother complexion”
- “refined skin”
Brightening effect Sometimes Noted
- “fades dark spots”
- “radiant appearance”
- “brightens dullness”
- “even skin tone”
Elegant texture Sometimes Noted
- “absorbs quickly”
- “lightweight feel”
- “non-sticky”
- “layers well”
Hydrating & plumping Sometimes Noted
- “moisturizing finish”
- “non-drying formula”
- “plump and firm”
- “healthy glow”
Slow results Sometimes Noted
- “not instant fix”
- “takes time”
- “requires patience”
- “cumulative effect”
Initial sensitivity Rarely Noted
- “slight tingling”
- “mild purging”
- “minor redness”
- “start slowly”
Scent preferences Rarely Noted
- “medicinal smell”
- “herbal scent”
- “wish it was unscented”
- “smell lingers”
Small quantity Rarely Noted
- “bottle too small”
- “finished quickly”
- “wish for bigger size”
- “30ml not enough”
Sources: lovi.care, anua.us, iherb.com, stylekorean.com, yesstyle.com, stylevana.com, and more
Questions and answers
What makes Anua Nano Retinol 0.3% + Niacin Renewing Serum a great fit for mature skin?
Which ingredients make this serum a good fit for mature skin?
This serum is a great fit for mature skin because retinol and adenosine help smooth texture and minimize fine lines, while niacinamide and hyaluronic acid support skin renewal and barrier repair. These ingredients work together to effectively address signs of aging while keeping the skin soft and calm.
What does Retinol do for mature skin?
Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. Using it at night helps the retinol and niacinamide smooth texture and soften fine lines without extra irritation.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and save this treatment for your evening routine to keep your skin calm. Using them at different times of day helps your skin handle both active ingredients safely and effectively without feeling overwhelmed.
How often should I use this serum?
Use this serum in your evening routine, starting about once a week and gradually increasing as your skin adjusts. This ingredient and strength help smooth texture and soften fine lines with a low risk of irritation.
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to cause breakouts or clog pores on mature skin, and initial sensitivity is low because it is free of harsh ingredients. It helps smooth texture and soften fine lines safely over time, though mild initial purging may occasionally happen when starting retinol.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.
Scientific Reports, 2024Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.
Auris, Nasus, Larynx, 2020Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment.
Aesthetic Plastic Surgery, 2018
Ingredients
Water, Niacinamide, Glycerin, Butylene Glycol, 1,2-Hexanediol, Panthenol, Hyaluronic Acid, Allantoin, Betaine, Tocopherol, Ethylhexylglycerin, Adenosine, Caprylyl Glycol, Xanthan Gum, Disodium Edta
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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