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Avène vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Avène and Sesderma are a French brand founded in 1990 and a Spanish brand founded in 1989, respectively. The French brand is loved for its gentle moisturizers, protective sunscreens, targeted serums, and soothing cleansers formulated with glycerin, suiting oily acne-prone skin and combination skin best. Conversely, Sesderma is beloved for its advanced serums and meticulously engineered formulas that suit sensitive, hyperpigmented, and aging skin types best. While both brands address acne-prone skin through standout treatments like the Tolerance Control Soothing Skin Recovery Balm, Cleanance, Hyaluron Activ B3 Concentrated Plumping Serum, and Azelac RU Serum, they differ in their foundational ingredients and primary skin type focuses.

Avène is a French skincare brand founded in 1990 and owned by Fondation Pierre Fabre.

pierre-fabre.comavene.co.ukaveneusa.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Avène and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Avène vs Sesderma products

Questions and answers

Avène or Sesderma: which is better?

Avène is better suited for a broader range of skin types and concerns, offering fifteen diverse products on this page compared to Sesderma's single option. Sesderma's Azelac RU Serum may help with dark spots and acne-prone skin, but Avène provides superior and high Lovi fit levels across multiple categories like dry, sensitive, and oily skin.

What is the difference between Avène and Sesderma?

Avene offers a much wider range of fifteen products featuring key ingredients like thermal water and glycerin, while Sesderma is represented by only one product on this page, the Azelac RU Serum. Reviewers note that Avene provides gentle sunscreens and cleansers, though some products contain fragrance, whereas Sesderma's single serum also includes fragrance.

Which is more affordable, Avène or Sesderma?

Price point is a consideration for Avène, as reviewers sometimes note it, while the page does not provide pricing information for Sesderma.

Which causes fewer breakouts, Avène or Sesderma?

Avène products on this page have a High Lovi fit for acne-prone skin and oily acne-prone skin, such as Cleanance sunscreen and Cleanance Cleansing Gel, whereas Sesderma is represented by Azelac RU Serum, which also has a High fit for acne-prone skin. Azelaic acid in Sesderma's formula is supported by research for improving acne.

Pharmaceutics, 2021

How does the founding year and country of origin compare between Avène and Sesderma?

Avène was founded in France in 1990, while Sesderma was founded in Spain in 1989.

Which brand offers more fragrance-free products, Avène or Sesderma?

Avene offers more fragrance-free products than Sesderma, with 7 out of 15 products on this page listing no fragrance, while Sesderma has none. Avene's fragrance-free options span cleansers, moisturizers, and thermal water.

What are the key ingredients featured across Avène products?

The key ingredients featured across Avène products on this page are thermal water and glycerin, supported by studies showing that glycerin-based emollients help improve skin condition.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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