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Avène vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Avène and Sesderma are trusted European skincare houses founded in 1990 and 1989, respectively, offering distinct formulations tailored to varied complexions. The French brand relies on science-backed formulations featuring hydrating glycerin, rich moisturizers, reliable sunscreens, targeted serums, and gentle cleansers that suit oily acne-prone skin and acne-prone skin best through products like the Tolerance Control Soothing Skin Recovery Balm, the Cleanance, and the Hyaluron Activ B3 Concentrated Plumping Serum. Meanwhile, the Spanish brand is beloved for advanced serums and meticulously engineered formulas utilizing botanical extracts and active compounds—such as the Azelac RU Serum—that suit sensitive, hyperpigmented, and aging skin types best. While both achieve a calm and radiant complexion, they differ as the former focuses on barrier restoration and the latter promotes refined texture.

Avène is a French skincare brand founded in 1990 and owned by Fondation Pierre Fabre.

pierre-fabre.comavene.co.ukaveneusa.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Avène and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Avène vs Sesderma products

Questions and answers

Avène or Sesderma: which is better?

Avène is better suited for a broader range of skin types and concerns, as the products on this page offer High to Superior Lovi fits for oily, acne-prone, dry, and sensitive skin, whereas Sesderma currently features only one serum listed.

What is the difference between Avène and Sesderma?

Avené offers a wide variety of products on this page with different fit levels across many skin types, whereas Sesderma is represented by just one product, the Azelac RU Serum. Avené fits best for oily and acne-prone skin types and features options with and without fragrance, while Sesderma's single product contains fragrance.

Which is more affordable, Avène or Sesderma?

Price point is sometimes noted for Avène as a drawback, while affordability details for Sesderma are not mentioned on this page.

Which causes fewer breakouts, Avène or Sesderma?

Avène helps control breakouts across its products on this page, whereas Sesderma is represented by only one product, Azelac RU Serum, which has a High fit for acne-prone skin.

Pharmaceutics, 2021

How many products from Avène do not contain fragrance compared to Sesderma?

Avène has 7 products on this page that list no fragrance, whereas Sesderma has 0 out of 1 products without fragrance.

Which brand has been on the market longer, Avène or Sesderma?

Sesderma has been on the market longer, having been founded in Spain in 1989, while Avène was founded in France in 1990.

What are the main key ingredients used across Avène products?

The main key ingredients used across Avène products on this page are thermal water and glycerin. Glycerin helps provide hydration and moisture for the skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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