Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence
Sodium hyaluronate · Dermatologic Therapy, 2022Topical use of dexpanthenol in skin disorders
Panthenol · American Journal of Clinical Dermatology, 2002The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Aloe barbadensis leaf juice · Iranian Journal of Medical Sciences, 2019Improvement of naturally aged skin with vitamin A (retinol)
Retinol · Archives of Dermatology, 2007Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris
Squalane · The Journal of Investigative Dermatology, 2006Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo
Retinol · International Journal of Cosmetic Science, 2017Psychophysical study of the effects of topical application of menthol in healthy volunteers
Menthol · Pain, 2006Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Retinol · The British Journal of Dermatology, 2019Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Ascorbyl glucoside · Journal of Periodontology, 2009Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Panax ginseng root extract · Journal of Ginseng Research, 2017Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo
Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling
Panax ginseng root extract · Journal of Ethnopharmacology, 2007Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin
Squalane · Scientific Reports, 2020Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf juice · Clinical Pharmacology, 2018Myristic acid reduces skin inflammation and nociception
Myristic acid · Journal of Food Biochemistry, 2022Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramides · Scientific Reports, 2022Calendula extract: effects on mechanical parameters of human skin
Calendula officinalis flower · Acta Poloniae Pharmaceutica, 2011Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np · International Journal of Dermatology, 2008Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia
Menthol · European Journal of Pain, 2014The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide · Journal of Cosmetic Dermatology, 2021Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging
Bentonite · Carbohydrate Polymers, 2017A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid · BioMed Research International, 2020Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide · Scientific Reports, 2024A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol · The Journal of Dermatological Treatment, 2017Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine · International Journal of Cosmetic Science, 2018Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Gluconolactone · The Australasian Journal of Dermatology, 1992Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid · Journal of Cosmetic Dermatology, 2024Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e · Journal of Cosmetic Dermatology, 2020Natural Arctium lappa fruit extract improves the clinical signs of aging skin
Arctium lappa root extract · Journal of Cosmetic Dermatology, 2008Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil
Avocado oil · Journal of Cosmetic Dermatology, 2020A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np · Skin Pharmacology and Physiology, 2022Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications
Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Palmitoyl oligopeptide · Journal of Cosmetic Dermatology, 2015Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study
Jojoba seed oil · Forschende Komplementarmedizin, 2012Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of Schisandra chinensis Extracts and Their Applicability in Skin Care Product
Schisandra chinensis fruit extract · Molecules, 2022A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid · Journal of Drugs in Dermatology, 2023In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing
Jasmonic acid · Journal of the European Academy of Dermatology and Venereology, 2014In vitro and in vivo anti-allergic effects of Arctium lappa L
Arctium lappa root extract · Experimental Biology and Medicine, 2008Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release
Oenothera biennis oil, Oenothera biennis evening primrose oil · Biomaterials Advances, 2022Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function
Propanediol · International Journal of Cosmetic Science, 2024Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model
Jojoba seed oil · Frontiers in Pharmacology, 2024Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations
Vitamin e · Journal of Cosmetic Dermatology, 2022Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol · International Journal of Cosmetic Science, 2010Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging
Schisandra chinensis fruit extract · International Journal of Molecular Sciences, 2018Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin
Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2008Damage and recovery of skin barrier function after glycolic acid chemical peeling and crystal microdermabrasion
Alumina · Dermatologic Surgery, 2004A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris
Terminalia ferdinandiana fruit extract · Dermatologic Therapy, 2020Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders
3-o-ethyl ascorbic acid · Polymers, 2023Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine · Journal of Cosmetic Dermatology, 2019Preparation, characterization, and application of polysaccharide-based emulsions incorporated with lavender essential oil for skin-friendly cellulosic support
Lavender essential oil · International Journal of Biological Macromolecules, 2021Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast
Squalane · Molecules, 2025Microbicidal activity of tripotassium phosphate and fatty acids toward spoilage and pathogenic bacteria associated with poultry
Myristic acid · Journal of Food Protection, 2005Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine · Molecules, 2024Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate · Arzneimittel-Forschung, 1998A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo
Rosa canina oil fruit, Shea butter · Journal of Cosmetic Dermatology, 2022A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants
Dimethicone · Ostomy/wound Management, 2005The evaluation of aluminum oxide crystal microdermabrasion for photodamage
Alumina · Dermatologic Surgery, 2001Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion
Alumina · Dermatologic Surgery, 2002The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine · Skin Research and Technology, 2003Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Propanediol · Molecules, 2021Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects
Cucumis sativus cucumber fruit extract juice, Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol · Journal of Cosmetic Dermatology, 2025Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e · Journal of Cosmetic Dermatology, 2024Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate · Scientific Reports, 2025Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients
3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026Genotoxicity of micro- and nano-particles of kaolin in human primary dermal keratinocytes and fibroblasts
Kaolin · Genes and Environment, 2020Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine · International Journal of Molecular Sciences, 2026Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study
Jojoba esters · Journal of Cosmetic Dermatology, 2008Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris
Capryloyl salicylic acid, Lipo-hydroxy acid · Journal of Drugs in Dermatology, 2013Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females
Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum
Caprylic capric triglyceride · Life, 2023Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid
Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998Clinical and histologic changes determine optimal treatment regimens for microdermabrasion
Alumina · The Journal of Dermatological Treatment, 2002Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos
Activated c, Ascorbyl glucoside · International Journal of Molecular Sciences, 2024Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021Facial disbiosis and UV filters
Octocrylene · Archives of Dermatological Research, 2024Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging
Jasmonic acid · Journal of Drugs in Dermatology, 2016An integrated network pharmacology and molecular docking approach to reveal the role of Arctigenin against Cutibacterium acnes-induced skin inflammation by targeting the CYP19A1
Arctium lappa root extract · Chemical Biology & Drug Design, 2024Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial
Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2023Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial
Shea butter · Lasers in Medical Science, 2025The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial
Bentonite · Journal of Cosmetic Dermatology, 2025Retrospective Review of Dermal Safety Studies of Organic Sunscreens
Octisalate, Homosalate · Journal of Drugs in Dermatology, 2025Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism
Palmitoyl tripeptide-1, Palmitoyl oligopeptide · Journal of Cosmetic Dermatology, 2026Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking
Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters
Gluconolactone · Skin Research and Technology, 2023Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial
Ascorbyl glucoside · Cureus, 2026Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration
Sodium pca · Biomaterials Advances, 2026
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