ISDIN K-Ox Eyes for mature skin

Questions and answers

What the research says

• Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

  Journal of Cosmetic Dermatology, 2026

• A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.

  Journal of Cosmetic Dermatology, 2015

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

  Journal of Cosmetic Dermatology, 2020

• Topical vitamin K oxide gel showed a non-significant trend toward faster resolution of pulsed dye laser-induced facial purpura compared to placebo in 20 subjects over a nine-day period.

  Journal of Drugs in Dermatology, 2009

• Topical application of a gel containing 2% phytonadione, 0.1% retinol, and 0.1% vitamins C and E reduced dark under-eye circles by decreasing haemostasis in 47% of 57 healthy Japanese adults and slightly decreased wrinkles after 8 weeks, while pigmentation was not clearly removed.

  Journal of Cosmetic Dermatology, 2004

• A new topical product containing retinol, alpha-hydroxy acids, arnica oil, ceramides, niacinamide, and phytonadione effectively treats actinic purpura by improving local circulation, thickening the skin, and repairing the skin barrier.

  The Journal of Clinical and Aesthetic Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical formulation containing hesperidin methyl chalcone inhibited skin oxidative stress, inflammation, and cytokine production induced by ultraviolet B irradiation in hairless mice.

  Photochemical & Photobiological Sciences, 2016

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Glycerin, Isohexadecane, Isopropyl Myristate, Ppg-15 Stearyl Ether, Peg-30 Dipolyhydroxystearate, Phytonadione Epoxide, Magnesium Sulfate, Phenoxyethanol, Parfum, Microcristallina Cera Wax Microcrystalline Cera Wax, Ci 77891 Titanium Dioxide, Sodium Dextran Sulfate, Acrylates C12-22 Alkyl Methacrylate Copolymer, Steareth-20, Hesperidin Methyl Chalcone, Disodium Edta, Hydrolyzed Hyaluronic Acid, Ethylhexylglycerin, Peg-8, Pentylene Glycol, Tocopherol, Chlorhexidine Digluconate, N-Hydroxysuccinimide, Bht, Potassium Sorbate, Dipeptide-2, Ascorbyl Palmitate, Palmitoyl Tetrapeptide-7, Citric Acid, Ascorbic Acid, Chrysin, Palmitoyl Tripeptide-1, Sodium Citrate, Biotin

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.