Anua PDRN Hyaluronic Acid Capsule 100 Serum for acne-prone skin
Hydrolyzed Hyaluronic Acid
Niacinamide
GlutathioneAverage
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate hydration for your combination skin, as multiple forms of hyaluronic acid like Hydrolyzed Hyaluronic Acid and Sodium Hyaluronate Crosspolymer provide deep moisture, while niacinamide helps regulate oil production.
- The serum is generally safe for your acne-prone skin, lacking harsh ingredients that could cause irritation.
- While it provides excellent moisturizing benefits, it lacks specific ingredients to target acne and blemishes directly.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.7Overall rating based on 300+ reviewsUsers consistently praise this serum for delivering the coveted "glass skin" look, offering deep hydration that plumps the skin without feeling heavy or greasy. While most find it excellent for barrier repair and instant glow, a minority feel it is simply a good hydrator rather than a "life-changing" treatment for the price.
Highlights
Deep hydration Mostly Mentioned
- “complexion feels so plump”
- “pure hydration”
- “inner glow”
- “moisture plumping effects”
Glass skin glow Often Mentioned
- “glassy skin look”
- “dewy finish”
- “radiant”
- “instant glow boost”
Lightweight texture Often Mentioned
- “watery yet viscous”
- “absorbs incredibly fast”
- “lightweight”
- “not sticky”
Makeup compatibility Sometimes Noted
- “makeup applies so smoothly”
- “layers well”
- “makeup sits beautifully”
Soothing & repair Sometimes Noted
- “calm with zero irritation”
- “strengthening skin barrier”
- “reduced redness”
Price vs volume Sometimes Noted
- “price feels way too high”
- “finish fast”
- “small bottle”
- “expensive for amount”
Breakouts Rarely Noted
- “blemishes appearing”
- “folliculitis”
- “caused small bumps”
Runny consistency Rarely Noted
- “runny”
- “slips through fingers”
- “evaporates quickly”
- “too thin”
Subtle results Rarely Noted
- “not life changing”
- “didn't do anything noticeable”
- “just a hydrator”
Texture issues Rarely Noted
- “sticky hands”
- “tacky finish”
- “pilling with emulsion”
Sources: lovi.care, anua.us, oliveyoung.com, stylekorean.com, yesstyle.com, skinsort.com, and more
Questions and answers
How well does Anua PDRN Hyaluronic Acid Capsule 100 Serum work for acne-prone skin?
This serum works moderately well for your acne-prone skin because it provides deep moisture and helps regulate oil without causing irritation, though it lacks specific ingredients to target breakouts directly. To fit this skin better, a moisturizing treatment needs effective ingredients that address blemishes while keeping oiliness in check.
Which ingredients make this serum a good fit for acne-prone skin?
Niacinamide and multiple forms of hyaluronic acid make this serum a fit by helping control oil and providing deep moisture without causing irritation. Acne-prone skin needs products with calming and blemish-targeting ingredients like Centella Asiatica and peptides alongside oil-balancing ingredients.
What does Hydrolyzed Hyaluronic Acid do for acne-prone skin?
Hydrolyzed hyaluronic acid helps balance moisture in acne-prone skin while supporting a calm, clear complexion. Depending on its molecular weight and formulation, it may help manage skin oil production and inflammation safely.
What does Niacinamide do for acne-prone skin?
Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Where does this serum go in a skincare routine for acne-prone skin?
This serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. While it provides good moisture and is generally safe, this skin needs a product containing targeted blemish-fighting ingredients to work best.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying it before your retinol to keep your skin hydrated and help reduce irritation. This product needs soothing ingredients like centella or green tea, and blemish-fighting ingredients like salicylic acid, to truly help acne-prone skin.
How often should I use this serum?
You can use this serum in your evening routine as an everyday treatment step, and some people may also use it in the morning or twice a day. Daily application helps keep your skin hydrated and smooth while being gentle on acne-prone skin, though this type of skin also needs specific ingredients to target breakouts directly.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is unlikely to clog pores or cause breakouts for acne-prone skin because it lacks harsh ingredients that typically cause irritation. While it provides good moisture and helps keep skin calm, a product of this type needs specific blemish-fighting ingredients to actively target acne.
Can I use this serum around the eyes or on my body?
You can use this serum safely around the eyes and on the body because it features a gentle formula with good skin tolerance. While it provides deep moisture with multiple forms of hyaluronic acid, acne-prone skin ultimately needs targeted blemish-fighting ingredients and soothing plant extracts for the best results.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability.
Aesthetic Plastic Surgery, 2026Profhilo gel combined with Dysport Botox significantly improved skin hydration, skin thickness, and GAIS scores compared to Dysport Botox injection alone in 19 participants seeking neck rejuvenation.
Dermatologic Therapy, 2022Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation.
Colloids and Surfaces. B, Biointerfaces, 2022Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.
American Journal of Surgery, 2005
Why other moisturizers fit acne-prone skin better
Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients.
The Australasian Journal of Dermatology, 1992Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023
Ingredients
Water, Butylene Glycol, Propanediol, Glycerin, Hydrolyzed Hyaluronic Acid, 1,2-Hexanediol, Niacinamide, Glyceryl Oleate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Hydrogenated Lecithin, Glutathione, Hydrolyzed Collagen, Hyaluronic Acid, Coptis Japonica Root Extract, Adenosine, Sodium Dna, Hydrolyzed Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Ocimum Sanctum Leaf Extract, Citric Acid, Curcuma Longa Root Extract, Corallina Officinalis Extract, Sodium Citrate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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