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SK-II vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SK-II and Sesderma are esteemed international skincare companies offering distinct approaches to complexion care. Skincare enthusiasts adore the Japanese pioneer for its luxurious moisturizers, potent serums, soothing masks, refreshing toners, and signature pitera formulations, which suit dry and dry sensitive skin best by improving pore area, roughness, and redness. Meanwhile, the Spanish brand is beloved for its advanced serums and meticulously engineered formulas featuring botanical extracts and active compounds that suit sensitive, hyperpigmented, and aging skin types. While both brands refine skin texture and promote radiant complexions through standout solutions like the Genoptics Ultraura Essence, Facial Treatment Essence, Facial Treatment Clear Lotion, and Azelac RU Serum, they differ fundamentally in their signature ingredients and targeted skin concerns.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II is a better fit overall for most shoppers on this page, as Lovi rates its products with High fits across multiple skin types, whereas Sesderma's sole product has low fits for dry and dry sensitive skin. Additionally, every SK-II product on this page lists no fragrance, while Sesderma's serum contains fragrance.

What is the difference between SK-II and Sesderma?

SK-II is a Japanese brand founded in 1980 that offers fragrance-free products on this page featuring Pitera, fitting dry, dry sensitive, and combination skin best. Sesderma is a Spanish brand founded in 1989 that features fragrance in its single serum on this page, which helps with dark spots and acne-prone skin.

Which is more affordable, SK-II or Sesderma?

The products on this page from SK-II and Sesderma do not include pricing information, so affordability cannot be compared here.

Which causes fewer breakouts, SK-II or Sesderma?

For breakouts, SK-II helps more with acne-prone skin because the products on this page include Genoptics Ultraura Essence, which has a Superior fit level for acne-prone skin, whereas Sesderma only features Azelac RU Serum, which has a High fit level.

Which brand has products formulated without fragrance, SK-II or Sesderma?

SK-II has fragrance-free products on this page, whereas the Sesderma product lists fragrance in its ingredients.

When were SK-II and Sesderma respectively founded, and in which countries?

SK-II was founded in 1980 in Japan, while Sesderma was founded in 1989 in Spain.

Which SK-II product achieves a Superior Lovi fit level for acne-prone skin?

The Genoptics Ultraura Essence from SK-II achieves a Superior Lovi fit level for acne-prone skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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