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SK-II vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SK-II and Sesderma are esteemed international skincare companies offering thoughtfully crafted formulas for diverse complexions. Japanese heritage brand SK-II relies on its signature ingredient, pitera, to elevate its transformative moisturizers, targeted serums, restorative masks, and balancing toners, suiting acne-prone and dry sensitive skin best. Meanwhile, Spanish brand Sesderma is beloved for its advanced serums and meticulously engineered formulas, which suit sensitive, hyperpigmented, and aging skin types best. While the former utilizes pitera to measurably improve pore area, roughness, and redness, the latter employs botanical extracts and active compounds to refine skin texture and promote a radiant complexion.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II is a better fit for overall skin variety because the products on this page achieve High to Superior Lovi fit levels across multiple skin types and have no fragrance, whereas Sesderma offers only a single serum with a fragrance. For acne-prone skin and skin with dark spots, Azelac RU Serum still helps with a High Lovi fit.

Pharmaceutics, 2021

What is the difference between SK-II and Sesderma?

SK-II is founded in Japan and offers multiple fragrance-free products on this page with High fits for dry, acne-prone, and sensitive skin, while Sesderma is founded in Spain and features an Azelac RU Serum that contains fragrance and has a High fit for acne-prone skin and dark spots.

Which is more affordable, SK-II or Sesderma?

This page does not provide pricing or affordability information for either SK-II or Sesderma.

Which causes fewer breakouts, SK-II or Sesderma?

For acne-prone skin, SK-II gets a Superior fit with Genoptics Ultraura Essence, while Sesderma's Azelac RU Serum gets a High fit. The products on this page by SK-II also contain no fragrance, which helps minimize irritation.

Pharmaceutics, 2021

How do the founding years and home countries of SK-II and Sesderma compare?

SK-II was founded in 1980 in Japan, whereas Sesderma was founded in 1989 in Spain.

Which products from SK-II and Sesderma contain fragrance?

Every SK-II product on this page is formulated without fragrance, while the Azelac RU Serum from Sesderma contains fragrance.

What is the key active ingredient used across SK-II products?

The key active ingredient used across the products on this page for SK-II is Pitera.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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