🇪🇸Spain

SK-II vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

SK-II and Sesderma are esteemed international skincare brands founded in the 1980s that offer meticulously engineered formulas. The Japanese brand is known for its luxurious moisturizers, potent serums, rejuvenating masks, and clarifying toners powered by its signature ingredient, pitera, while the Spanish brand is beloved for its advanced serums and active compounds. SK-II suits combination, oily, normal, and dry skin best, whereas Sesderma suits sensitive, hyperpigmented, and aging skin types best. These two brands ultimately differ in their regional origins, primary formulations, and ideal skin types, though both utilize botanical science to refine skin texture and promote a radiant complexion.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II has more products on this page with a High Lovi fit across multiple skin types, whereas Sesderma offers only a single serum with mixed fit levels.

What is the difference between SK-II and Sesderma?

SK-II is a Japanese brand offering multiple fragrance-free products on this page like the Genoptics Ultraura Essence, which has a Superior fit for acne-prone skin, whereas Sesderma is a Spanish brand represented here by the Azelac RU Serum, which contains fragrance and achieves a High fit for dark spots.

Which is more affordable, SK-II or Sesderma?

This page does not compare prices for SK-II and Sesderma.

Which causes fewer breakouts, SK-II or Sesderma?

For acne-prone skin, the products on this page by SK-II reach up to a Superior fit level with Genoptics Ultraura Essence, while Sesderma's Azelac RU Serum reaches a High fit level.

Pharmaceutics, 2021

Which brand has been around longer, SK-II or Sesderma?

SK-II has been around longer, having been founded in 1980 in Japan compared to Sesderma, which was founded in 1989 in Spain.

Do SK-II products contain fragrance, and how does that compare to Sesderma?

SK-II products on this page list no fragrance in their ingredients, whereas the Azelac RU Serum by Sesderma does contain fragrance.

Which country are SK-II and Sesderma originally from?

SK-II is originally from Japan, while Sesderma is originally from Spain.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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