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SK-II vs Sesderma

Rated by Lovi 路 Unbiased, science-based skincare AI trained on real user outcomes 路 How the Fit score works

SK-II and Sesderma are distinguished skincare houses originating from Japan and Spain, respectively. SK-II champions nourishing moisturizers, targeted serums, restorative masks, clarifying toners, and gentle formulations powered by pitera, while the second brand is beloved for advanced serums and meticulously engineered formulas featuring botanical extracts and active compounds. The Japanese brand suits dry sensitive skin and combination skin best, alongside catering to mature skin and addressing acne-prone or dark spot concerns, whereas the Spanish brand aligns with sensitive, hyperpigmented, and aging skin types while offering solutions for acne-prone skin. Ultimately, they differ through the former's reliance on pitera to refine pore area, roughness, and redness, contrasted with the latter's synergistic actives designed to refine skin texture and promote a radiant complexion.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II is the better choice for most shoppers on this page, as the products on this page achieve High fits for a wider range of skin types compared to Sesderma. Its fragrance-free formulas feature Pitera and help care for dry sensitive, combination, and acne-prone skin.

What is the difference between SK-II and Sesderma?

SK-II fits dry sensitive skin, combination skin, and acne-prone skin best with its fragrance-free products on this page, while Sesderma is represented by Azelac RU Serum which contains fragrance.

Which is more affordable, SK-II or Sesderma?

Neither brand is more affordable on this page because pricing details are not available for either SK-II or Sesderma.

Which causes fewer breakouts, SK-II or Sesderma?

For acne-prone skin, SK-II helps with a Superior fit on this page, whereas Sesderma's Azelac RU Serum is rated High. Azelaic acid helps reduce acne-prone skin issues.

Pharmaceutics, 2021

Which brand uses Pitera as a key ingredient across its products, SK-II or Sesderma?

SK-II uses Pitera as a key ingredient across the products on this page, whereas Sesderma does not feature it.

Between SK-II and Sesderma, which brand offers a broader range of skincare products on this page?

SK-II offers a much broader range of products on this page, including multiple moisturizers, serums, a toner, a mask, and a cleansing oil, whereas Sesderma is represented by only a single serum.

Do any products from SK-II or Sesderma contain fragrance?

Every product from SK-II on this page lists no fragrance in its ingredients, while Sesderma's Azelac RU Serum contains fragrance.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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