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SK-II vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

SK-II and Sesderma are distinguished skincare brands that offer targeted solutions for varying complexions. The Japanese brand is known for luxurious moisturizers, potent serums, clarifying toners, and restorative masks anchored by pitera, while the Spanish brand is beloved for advanced serums and meticulously engineered formulas featuring botanical extracts and active compounds. Both brands suit dry, acne-prone, sensitive, hyperpigmented, and aging skin types, though they differ through distinct formulations designed to address imbalances, refine texture, and promote a radiant complexion.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

en.wikipedia.orgdiscoversk-ii.wixsite.comglossy.co

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular SK-II and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular SK-II vs Sesderma products

Questions and answers

SK-II or Sesderma: which is better?

SK-II is a better choice for most shoppers on this page since the products on this page list no fragrance, whereas Sesderma includes fragrance in its serum. Lovi gives SK-II products a High fit across a wide range of skin types.

What is the difference between SK-II and Sesderma?

SK-II offers a broader range of fragrance-free products on this page that Lovi rates as a High fit for dry, acne-prone, and oily skin, whereas Sesderma is represented by a single serum that contains fragrance. For treating acne and dark spots, Sesderma Azelac RU Serum helps with a High fit, while SK-II features options like Genoptics Ultraura Essence that achieves a Superior fit for acne-prone skin.

Pharmaceutics, 2021

Which is more affordable, SK-II or Sesderma?

I am sorry, but the page facts do not provide pricing or affordability details for either SK-II or Sesderma.

Which causes fewer breakouts, SK-II or Sesderma?

For acne-prone skin, the products on this page by SK-II have a High to Superior Lovi fit level, whereas Sesderma's Azelac RU Serum holds a High fit. Both brands help manage breakouts effectively.

Which brand has been around longer, SK-II or Sesderma?

SK-II has been around longer, having been founded in Japan in 1980, while Sesderma was founded in Spain in 1989.

Do SK-II products contain fragrance, whereas Sesderma products contain fragrance?

The products on this page from SK-II list no fragrance, whereas the Azelac RU Serum from Sesderma contains fragrance.

What is the key ingredient featured across SK-II products?

The key ingredient featured across the products on this page for SK-II is Pitera.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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