Shiseido Treatment Softener for dry sensitive skin

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Ethanol as a preservative in topical creams reduced the dermal penetration of hydrophilic surrogates by about 40% and lipophilic surrogates by about 20% on intact skin while having minimal impact on irritated skin, and it altered biophysical skin properties depending on the skin condition.

  Pharmaceutics, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• A Hamamelis virginiana leaf extract increased LOXL1 expression twofold, decreased elafin synthesis, restored functional elastic fibers, reduced nonfunctional elastin aggregates, decreased wrinkles, and improved skin firmness.

  Journal of Cosmetic Science, 2018

• Hamamelis bark proanthocyanidins strongly increased the proliferation of cultured human keratinocytes and reduced transepidermal water loss and erythema formation in SLS-irritated skin, whereas the polysaccharide fraction had no effect.

  Phytochemistry, 2001

• Witch hazel bark extract and hamamelitannin showed pronounced anti-inflammatory activity, supported keratinocyte migration in a wound healing assay, and inhibited Staphylococcus aureus growth, whereas their skin microbiota metabolite ellagic acid stimulated inflammatory mediator release.

  Journal of Ethnopharmacology, 2025

• Sapindus mukorossi seed oil promoted wound healing, cell proliferation, migration, and exhibited anti-inflammatory and antimicrobial activities in cells and in rats compared to untreated controls.

  International Journal of Molecular Sciences, 2019

• Sapindus mukorossi flower water extract exhibited antioxidant, antibacterial against Cutibacterium acnes, and anti-inflammatory activities by reducing pro-inflammatory cytokines in in vitro experiments.

  Current Issues in Molecular Biology, 2025

• Caprine dermal scaffolds prepared using 5% Sapindus mukorossi fruit pericarp extract effectively achieved complete decellularization while preserving extracellular matrix architecture and promoted full-thickness skin wound healing in rabbits comparable to autografts.

  Journal of Biomaterials Applications, 2025

• Oral and topical botanical products containing ingredients like ashwagandha, saffron, l-theanine, and tocopherol reduced facial redness and pigmentation and improved sleep and certain mood parameters in healthy females with sensitive skin compared to baseline.

  Journal of Clinical Medicine, 2022

• Topical l-theanine pretreatment suppresses TPA-induced acute skin inflammation, ear edema, erythema, vascular permeability, and hyperplasia in mice by downregulating endothelial PECAM-1 and neutrophil infiltration and activation.

  Chemico-biological Interactions, 2018

Ingredients

Water, Dipropylene Glycol, Sd Alcohol 40-B Alcohol Denat, Glycerin, Diglycerin, Peg Ppg-14 7 Dimethyl Ether, Peg-20, Phenoxyethanol, Methylparaben, Carbomer, Erythritol, Parfum, Disodium Edta, Potassium Hydroxide, Butylene Glycol, Linalool, Sapindus Mukorossi Peel Extract, Sodium Metabisulfite, Citronellol, Geraniol, Magnesium Chloride, Theanine, Calcium Chloride, Serine, Witch Hazel Leaf Extract, Zingiber Aromaticus Extract, Sodium Acetylated Hyaluronate, Tocopherol, Artemisia Princeps Leaf Extract, Sodium Hyaluronate, Kirishima Mineral Spring Water, Mukurossi Extract, Brightening Lempuyang Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.