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Neutrogena vs Sesderma

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Neutrogena and Sesderma are a pair of esteemed skincare brands from America and Spain that offer thoughtful ranges of moisturizers, sunscreens, cleansers, toners, and advanced serums. The American line relies on trusted ingredients like glycerin, hyaluronic acid, and dimethicone to suit sensitive and mature skin best, whereas the Spanish brand is beloved for meticulously engineered formulas that also cater to hyperpigmented and aging skin types. While both provide targeted care for concerns like acne through standout items such as the Daily Facial Moisturizer and the Azelac RU Serum, they differ in their foundational approaches to scientific backing and botanical compounds.

Neutrogena is an American skincare brand founded in 1930 and owned by Kimberly-Clark Corporation since 2026.

investor.kimberly-clark.comen.wikipedia.orginvestors.kenvue.com

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

skinexpert.sesderma.comsesderma.com

This page compares some of the most popular Neutrogena and Sesderma products; for every product of both brands, with a fit score for your own skin, use the Lovi app.

Popular Neutrogena vs Sesderma products

Questions and answers

Neutrogena or Sesderma: which is better?

Neutrogena is the better choice for most shoppers on this page, offering dozens of options with a High or Superior Lovi fit for skin types like sensitive, mature, and dry skin. Sesderma only features one product on this page, the Azelac RU Serum, which has a High Lovi fit for acne-prone skin, skin with dark spots, and combination skin.

What is the difference between Neutrogena and Sesderma?

Neutrogena offers a wide range of moisturizers, sunscreens, and cleansers that Lovi rates best for sensitive, mature, and dry skin, while Sesderma features just one serum on this page. Furthermore, Neutrogena products on this page mostly list no fragrance, whereas the Sesderma product includes fragrance.

Which is more affordable, Neutrogena or Sesderma?

The products on this page do not provide pricing information to determine which brand is more affordable.

Which causes fewer breakouts, Neutrogena or Sesderma?

Neutrogena has an Average to High Lovi fit for acne-prone skin across many products on this page, whereas Sesderma offers a single product, Azelac RU Serum, which has a High Lovi fit for acne-prone skin.

How do the founding years and countries of origin compare between Neutrogena and Sesderma?

Neutrogena was founded in the United States in 1930, whereas Sesderma was founded in Spain in 1989.

Which Neutrogena products contain fragrance compared to Sesderma's Azelac RU Serum?

Among the products on this page, Neutrogena has four items containing fragrance: sun fresh derm care, Spot Controlling Facial Wash, Oil Balancing Facial Wash, and Blackhead Eliminating Cleansing Toner. In comparison, Sesderma's Azelac RU Serum also lists fragrance.

What is the Lovi fit level of Sesderma's Azelac RU Serum for acne-prone skin?

Lovi rates Sesderma's Azelac RU Serum as having a High fit for acne-prone skin.

Research behind their key ingredients

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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