Anua PDRN Hyaluronic Acid Capsule 100 Serum for mature skin
Hydrolyzed Hyaluronic Acid
Niacinamide
GlutathioneAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for mature skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum offers excellent hydration for your normal skin, with multiple forms of hyaluronic acid and glycerin providing humectant action and niacinamide supporting barrier repair. While beneficial for general skin health, these ingredients are not specifically targeted to address your primary concern of wrinkles and fine lines.
- The formula is safe for your normal skin, as it lacks harsh or prohibited ingredients that could cause irritation.
- It provides good moisturizing and plumping effects due to the presence of various hyaluronic acid derivatives.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
People Say
★4.7Overall rating based on 300+ reviewsUsers consistently praise this serum for delivering the coveted "glass skin" look, offering deep hydration that plumps the skin without feeling heavy or greasy. While most find it excellent for barrier repair and instant glow, a minority feel it is simply a good hydrator rather than a "life-changing" treatment for the price.
Highlights
Deep hydration Mostly Mentioned
- “complexion feels so plump”
- “pure hydration”
- “inner glow”
- “moisture plumping effects”
Glass skin glow Often Mentioned
- “glassy skin look”
- “dewy finish”
- “radiant”
- “instant glow boost”
Lightweight texture Often Mentioned
- “watery yet viscous”
- “absorbs incredibly fast”
- “lightweight”
- “not sticky”
Makeup compatibility Sometimes Noted
- “makeup applies so smoothly”
- “layers well”
- “makeup sits beautifully”
Soothing & repair Sometimes Noted
- “calm with zero irritation”
- “strengthening skin barrier”
- “reduced redness”
Price vs volume Sometimes Noted
- “price feels way too high”
- “finish fast”
- “small bottle”
- “expensive for amount”
Breakouts Rarely Noted
- “blemishes appearing”
- “folliculitis”
- “caused small bumps”
Runny consistency Rarely Noted
- “runny”
- “slips through fingers”
- “evaporates quickly”
- “too thin”
Subtle results Rarely Noted
- “not life changing”
- “didn't do anything noticeable”
- “just a hydrator”
Texture issues Rarely Noted
- “sticky hands”
- “tacky finish”
- “pilling with emulsion”
Sources: lovi.care, anua.us, oliveyoung.com, stylekorean.com, yesstyle.com, skinsort.com, and more
Questions and answers
How well does Anua PDRN Hyaluronic Acid Capsule Serum work for mature skin?
This serum works well to keep your skin hydrated, but it is an average fit for mature skin because it lacks targeted ingredients for fine lines. A product of this type needs effective anti-wrinkle ingredients and nourishing agents to properly address the needs of mature skin.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022
Which ingredients make this serum a good fit for mature skin?
This serum contains multiple forms of hyaluronic acid, glycerin, and niacinamide that help keep mature skin hydrated and smooth. While it provides good moisture, a product of this type needs targeted anti-wrinkle ingredients to fully address the signs of mature skin.
Clinical, Cosmetic and Investigational Dermatology, 2017Dermatologic Therapy, 2022
What does Hydrolyzed Hyaluronic Acid do for mature skin?
Hydrolyzed hyaluronic acid helps mature skin by significantly boosting skin hydration, improving elasticity, and reducing the look of deep wrinkles. It is unlikely to cause irritation, making it a well-suited choice for keeping dry and aging skin looking smooth.
Archives of Dermatological Research, 2024Colloids and Surfaces. B, Biointerfaces, 2022
What does Niacinamide do for mature skin?
Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Where does this serum go in a skincare routine for mature skin?
This treatment goes in the evening step of your routine, right before your moisturizer. Mature skin also benefits from active ingredients like peptides and antioxidants to help target fine lines and wrinkles.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol, applying the serum before your retinol product to help keep your skin hydrated and comfortable. This pairing is unlikely to cause irritation because the formula is safe and lacks harsh ingredients, though mature skin also needs targeted anti-aging ingredients like peptides or retinoids to properly address wrinkles and fine lines.
How often should I use this serum?
This serum works well in your evening routine, where you can apply it daily after cleansing and toning. Mature skin needing better care for wrinkles and fine lines benefits most from treatment products loaded with targeted anti-aging actives and collagen-boosting peptides.
Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015
Can this serum clog pores, cause breakouts or purging for mature skin?
This serum is unlikely to clog pores or cause breakouts for mature skin because the formula lacks heavy or harsh ingredients that typically cause irritation. To properly care for mature skin, a product of this type needs firming peptides and antioxidants to help smooth fine lines and improve elasticity.
Can I use this serum around the eyes or on my body?
You can use this serum around the eyes and on your body to keep skin soft and hydrated, though mature skin often needs specialized ingredients like peptides or retinoids to properly smooth out deep wrinkles and fine lines.
Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.
Dermatologic Therapy, 2022Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.
Drug Delivery, 2017Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025
Ingredients
Water, Butylene Glycol, Propanediol, Glycerin, Hydrolyzed Hyaluronic Acid, 1,2-Hexanediol, Niacinamide, Glyceryl Oleate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Hydrogenated Lecithin, Glutathione, Hydrolyzed Collagen, Hyaluronic Acid, Coptis Japonica Root Extract, Adenosine, Sodium Dna, Hydrolyzed Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Ocimum Sanctum Leaf Extract, Citric Acid, Curcuma Longa Root Extract, Corallina Officinalis Extract, Sodium Citrate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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