SK-II Genoptics Ultraura Essence for sensitive skin

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Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Application of Galactomyces ferment filtrate skin care formula significantly reduced the net values and daily fluctuation of facial pore area, roughness, and redness in young Japanese women.

  Journal of Clinical Medicine, 2021

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.

  Arzneimittel-Forschung, 2000

• Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.

  Auris, Nasus, Larynx, 2020

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of ascorbic acid 2-glucoside combined with laser gingival depigmentation reduced pigmentation recurrence and increased patient satisfaction at nine months in 20 participants with physiologic gingival hyperpigmentation compared to laser depigmentation alone.

  Cureus, 2026

• Ascorbic acid 2-glucoside at 1.8% showed similar protective effects against oxidative stress compared to 15% ascorbic acid in human skin models despite a lower concentration, and demonstrated superior chemical stability.

  International Journal of Cosmetic Science, 2021

• Topical application of undecylenoyl phenylalanine 2% significantly lightened solar lentigines on the hands compared to vehicle control in 30 patients, with moderate to marked improvement and minimal side-effects.

  Clinical and Experimental Dermatology, 2010

• Nanostructured lipid carriers efficiently deliver undecylenoyl phenylalanine into the skin with higher accumulation and sustained release compared to emulsion and ethanol formulations, showing promise for topical treatment of hyperpigmentation.

  Advanced Pharmaceutical Bulletin, 2023

• Solid lipid nanoparticles containing Undecylenoyl phenylalanine achieved enhanced cutaneous uptake, spherical morphology with a particle size of 218.6 nm, and an entrapment efficiency of 87.31% while successfully inhibiting the tyrosinase enzyme to stop melanogenesis.

  Journal of Cosmetic Dermatology, 2022

• Saccharomycopsis Ferment Filtrate inhibits lipopolysaccharide-induced nitric oxide production and iNOS protein expression in RAW264.7 macrophages and protects artificial epidermis against lipopolysaccharide- or ultraviolet radiation-induced damages.

  Journal of Dermatological Science, 2006

Ingredients

Nicotinamide W, D-Pantothenyl Alcohol, Sk-Ii Pitera Concentrate, L-Ascorbic Acid 2-Glucoside, Undecylenoyl Phenylalanine, Inosit, Nelumbo Nucifera Extract, Chilicit, Sucrose Fatty Acid Ester, Concentrated Glycerin, Glyceryl Triethylhexanoate, Peg1540, Lauroyl Di Phytosteryl Octyldodecyl Glutamate, Crosslinked Silicone Reticulated Silicone Block Copolymer, Boron Nitride, Titanium Mica, Tri Caprylic Capric Acid Glyceryl, Poe Sorbitan Laurate, Bg, Acrylic Acid Methacryl Acid Alkyl Copolymer, Yellow Fe Oxide, Methylhydrogenpolysiloxane, Polyacrylamide, Plasma-Fluid Isoparaffin, Poe Lauryl Ether, Amp, Xanthan Gum, Benzyl Alcohol, Pentylene Glycol, Phenoxyethanol, Edetate, Benzoin Acid Salts, Parabens, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.