ANUA Heartleaf 70 Mud Cream Mask for acne-prone skin

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Questions and answers

What the research says

• Asiatic acid-loaded solid lipid microparticles stabilized with poloxamer-188 reduced porphyrin intensity, enhanced skin barriers, and improved skin hydration and brightness in fifteen participants with mild-to-moderate acne.

  International Journal of Pharmaceutics, 2024

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

  Journal of Cosmetic Dermatology, 2025

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream.

  Clinical, Cosmetic and Investigational Dermatology, 2016

• Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution.

  Molecules, 2019

• Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration.

  Gels, 2023

• Vectorization of high molecular weight hyaluronic acid with clay enabled its penetration into deeper skin layers and led to a significant clinical reduction in fine lines in the crow's feet area compared to placebo after 28 days.

  Skin Research and Technology, 2024

• Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite demonstrated superior moisture-adsorption and retention compared to hyaluronic acid, good UV-protection ability, negligible dermal irritation, and prominent moisture-retention efficacy on human stratum corneum when formulated into a cosmetic cream.

  Carbohydrate Polymers, 2017

• Twice-weekly use of a clay mask over 4 weeks in 75 adults with oily or combination skin improved acne-related outcomes, sebum content, skin evenness, hydration, and reduced dryness and irritation.

  Skin Research and Technology, 2023

• Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline.

  Forschende Komplementarmedizin, 2012

• A pharmaceutical formulation containing therapeutic clay from Ocara, Brazil, promoted greater formation of collagen fibers, regeneration of the deep dermis at seven days, and reepithelialization with continuous granulation tissue formation at 14 days in rat skin wounds compared to untreated controls.

  Materials Science & Engineering. C, Materials for Biological Applications, 2014

• Topical clay application increased the number of collagen fibres in rat skin at 7 days compared with control skin (51.74% vs. 43.39%), but showed no further increase at 14 days.

  Clinical and Experimental Dermatology, 2012

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream.

  International Journal of Cosmetic Science, 2008

Ingredients

Water, Kaolin, Houttuynia Cordata Extract, Cetearyl Alcohol, Caprylic Capric Triglyceride, Glycerin, Bergamot Oil Fruit, Centella Asiatica Leaf Extract, Glyceryl Stearate Se, Panthenol, Pentylene Glycol, 1,2-Hexanediol, Caprylyl Glycol, Dipotassium Glycyrrhizate, Ethylhexylglycerin, Dipropylene Glycol, Butylene Glycol, Madecassic Acid, Asiatic Acid, Asiaticoside, Tocopherol, Xanthan Gum

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.