Sesderma Azelac RU Liposomal Serum for dry sensitive skin
Azelaic Acid
Tranexamic Acid
Retinol
Niacin
4-ButylresorcinolAverage
- AverageDry Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for dry sensitive skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate brightening for your dry and sensitive skin due to 4-butylresorcinol and tranexamic acid, which help to even skin tone, but the presence of alcohol denat and retinol may cause irritation.
- Glycerin provides humectant action to address dryness, but the formula lacks sufficient emollient and occlusive ingredients to fully hydrate your dry or flaky skin.
- The product is generally safe for your skin, with a low risk of irritation from the included ingredients.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.2Overall rating based on 100+ reviewsBased on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.
Highlights
Fast absorption Mostly Mentioned
- “absorbing very fast”
- “lightweight”
- “no oily residue”
- “sinks deep into skin”
Fades dark spots Often Mentioned
- “huge difference in pigmentation”
- “removed stains from face”
- “fades spots fast”
- “marks down to faint shadows”
Improves texture Often Mentioned
- “skin smooth and luminous”
- “leaves skin glowy”
- “soft and alive”
- “texture is better”
Acne control Sometimes Noted
- “kept breakouts at bay”
- “pimples heal faster”
- “good for acne”
- “prevented new imperfections”
Drying effect Sometimes Noted
- “cheeks felt tight”
- “can dry you out”
- “needs moisturizer”
- “slightly aggressive initially”
High price Rarely Noted
- “expensive”
- “small bottle”
- “pricey for the size”
Slow results Rarely Noted
- “didn't see any effect”
- “oldest marks still there”
- “not a magic wand”
- “took forever to work”
Sticky finish Rarely Noted
- “sticky at first”
- “slight tacky feel”
- “feels a bit sticky”
Sources: lovi.care, notino.ie, influenster.com, skinsort.com, perfumesclub.co.uk, makeup.uk, and more
Questions and answers
How well does Sesderma Azelac RU Serum work for dry sensitive skin?
Sesderma Azelac RU Liposomal Serum works moderately well for dry sensitive skin by brightening and even-toning through active ingredients like 4-butylresorcinol and tranexamic acid, though alcohol denat and retinol may cause irritation. While glycerin helps with dryness, the formula lacks enough softening and sealing ingredients to fully care for flaky skin. A product of this type needs rich moisturizing components and skin barrier support to properly nourish and protect dry skin without any risk of irritation.
Which ingredients make this serum a good fit for dry sensitive skin?
This serum works for your dry sensitive skin due to glycerin, which helps address dryness. However, because it lacks enough softening and sealing ingredients to fully care for dry skin, a product of this type needs rich moisturizing components and skin barrier support to keep dry skin comfortable.
What does Azelaic Acid do for dry sensitive skin?
Azelaic acid is generally not an ideal fit for dry sensitive skin because it may cause stinging, irritation, or dryness, though it can help calm redness and soothe inflammation when formulated gently. To work well for dry sensitive skin, a product of this type needs calming plant extracts, rich moisturizers, and barrier-repairing ingredients to keep the skin soft and comfortable.
What does Tranexamic Acid do for dry sensitive skin?
Tranexamic acid helps dry sensitive skin by repairing the skin barrier and soothing irritation. It works well to calm redness and restore moisture without causing heavy side effects.
International Journal of Dermatology, 2014Clinical, Cosmetic and Investigational Dermatology, 2024
Where does this serum go in a skincare routine for dry sensitive skin?
This treatment serum goes in the evening routine after your cleansing and soothing steps, and before your moisturizer. Treatments with actives are best used at night for simplicity and extra safety around sun exposure.
Can I use this serum with vitamin C, and in what order?
You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night, as the formula includes retinol and alcohol denat that may irritate your dry sensitive skin if layered together. To care for this skin type properly, a product needs gentle soothing ingredients along with rich sealing softeners to prevent flaking and lock in moisture.
How often should I use this serum?
This serum is used in the evening routine once a week for dry sensitive skin, and people who tolerate it well and see good results can carefully use it more often. It helps even skin tone, but a product of this type needs richer nourishing oils, butters, and protective sealants to fully comfort dry skin.
Can this serum clog pores, cause breakouts or purging for dry sensitive skin?
This serum is unlikely to clog pores or cause breakouts for dry sensitive skin, though alcohol denat and retinol may cause irritation. A product for this skin needs rich softening and sealing ingredients to fully lock in moisture and prevent flaking.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).
What the research says
Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Benzyl Alcohol, Benzoic Acid, and Sodium Benzoate can be used safely in cosmetic formulations at concentrations up to 5%, and Benzyl Alcohol is safe up to 10% in hair dyes, despite causing nonimmunologic contact reactions.
International Journal of Toxicology, 2001Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.
Pharmaceutics, 2021Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.
Dermatology and Therapy, 2024Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.
Journal of the European Academy of Dermatology and Venereology, 2023Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks.
Journal of Cosmetic Dermatology, 20164-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks.
Journal of the European Academy of Dermatology and Venereology, 2013Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications.
Molecular Pharmaceutics, 2017
Why other serums fit dry sensitive skin better
- Retinol in this serum
Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019 Tocopherol succinate-loaded ethosomal gel increased skin deposition, stability, moisture, and mechanical properties in 13 human subjects compared to a control gel over 12 weeks.
Journal of Cosmetic Dermatology, 2022In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.
Skin Pharmacology and Physiology, 2026
Ingredients
Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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