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ISDIN Flavo-C Serum for mature skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

ISDIN Flavo-C Serum

High

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

A great choice for mature skin; a few serums fit it even better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your normal skin, this serum offers excellent antioxidant protection and brightening due to ascorbic acid and ginkgo biloba leaf extract, which also support collagen synthesis.
  • While it provides general skincare benefits, the formulation is not specialized for your main goal of addressing wrinkles and fine lines.
  • The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
  • Apply this serum after your toner and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • You can apply the serum on dry skin for the best results against fine lines.
  • Always do a patch test before your first use and avoid the sensitive eye area.

People Say

★4.6Overall rating based on 200+ reviews

This serum is highly regarded for its ability to brighten dull skin, reduce hyperpigmentation, and smooth fine lines, making it particularly effective for mature, dehydrated, or sun-damaged complexions. The formula is frequently praised for being lightweight and fast-absorbing, and for providing significant hydration. A small number of users with sensitive skin have reported experiencing irritation or redness.

Highlights

  • Brightens skin tone Often Mentioned
    • “My hyperpigmentation has lightened and skin looks more even, even shines more.”
    • “Gives a flawless and illuminating results.”
    • “I've seen good results with skin brightening, hydration and smoothing of fine lines.”
    • “This boosts collagen and makes the face brighter and tones the skin.”
  • Hydrates and smooths Often Mentioned
    • “I am more on a dehydrated side and this helps me look hydrated and smooth.”
    • “Helps reduce wrinkles and hydrate all day and all night.”
    • “I've seen good results with skin brightening, hydration and smoothing of fine lines.”
    • “Feel vibrant and refreshed with supple, moisturized skin.”
  • Lightweight, fast-absorbing Sometimes Noted
    • “I like how it is light not thick... love it.”
    • “The serum absorbs quickly so you can apply your moisturizer right away.”
    • “Its lightweight formula absorbs quickly, making it an excellent addition to any morning skincare routine.”
    • “No scent....which I like. The serum absorbs quickly.”
  • Frustrating packaging Rarely Noted
    • “I like the actual product, but the packaging is awful, I've already lost three bottles the applicator pops off.”
    • “I had been using the Flavo-C ampoules and loved the serum inside. But I've nicked myself one too many times while snapping the glass top off.”
    • “The serum is too thick for me and I feel I waste a lot of the product when tipping the vial.”
    • “Challenging packaging.”
  • Irritates sensitive skin Rarely Noted
    • “I think the serum is too strong for my face as it has burned and left very rough and a peeling face.”
    • “When i put the Day and night cream on it stings so I am afraid I am not able to use this product.”
    • “Super Irritating... Most Vitamin C serums oxidize and leave a yellow/orange cast on face.”
    • “If you have sensitive skin, you might experience some redness after the first application.”
  • Unpleasant smell Rarely Noted
    • “While I do like the product, the smell is very off-putting.”
    • “It's a very strong, unpleasant herbal-like scent.”
    • “It is so bad that I emailed customer service to see if it was in fact spoiled.”
    • “So I'm holding my nose and continuing to use it up.”

Sources: lovi.care, judge.me, dermapproved.com, newbeauty.com, walmart.com, frenchpharmacy.com, and more

Questions and answers

What makes ISDIN Flavo-C a great fit for mature skin?

ISDIN Flavo-C Serum is a great fit for mature skin because it brings strong antioxidant protection and brightening from ascorbic acid and ginkgo biloba leaf extract, which also help support collagen. It is unlikely to cause irritation on normal skin since it lacks harsh ingredients.

Journal of Cosmetic Dermatology, 2020Drug Development and Industrial Pharmacy, 2023

Which ingredients make this serum a good fit for mature skin?

Ascorbic acid and ginkgo biloba leaf extract make this serum a good fit by providing antioxidant protection, brightening the skin, and supporting collagen synthesis. Lactic acid and propylene glycol also help by gently hydrating and conditioning the skin with a very low risk of irritation.

Journal of Cosmetic Dermatology, 2020Drug Development and Industrial Pharmacy, 2023

What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.

Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2023

What does Ginkgo Biloba Extract do for mature skin?

Ginkgo Biloba Extract helps mature skin by smoothing out fine lines and keeping it soft and well-hydrated. It may also improve skin texture and firmness with regular use.

Drug Development and Industrial Pharmacy, 2023International Journal of Cosmetic Science, 2010

Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine step, as placed by Lovi routines for simplicity and extra safety around sun exposure. Some serums can also be used in the morning or twice a day.

Can I use it with retinol, and in what order?

You can use this serum alongside retinol by applying the serum in your morning routine and your retinol at night to avoid overwhelming your skin. This helps your skin stay bright and protected during the day while your retinol works overnight, and the gentle formula is unlikely to cause irritation.

How often should I use this serum?

You can use this serum in your evening routine, and some of them may also be used in the morning or twice a day. It has a very safe formula with no harsh ingredients, making it unlikely to irritate your skin.

Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. It features an excellent safety profile without harsh ingredients that typically trigger irritation or congestion.

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers.

    Journal of Cosmetic Dermatology, 2020

  • Topical application of Ginkgo biloba cream for two weeks reduced wrinkles and improved skin shape, texture, and tautness in human volunteers compared to baseline.

    Drug Development and Industrial Pharmacy, 2023

  • Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

    Experimental Dermatology, 2003

  • Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

    Journal of Periodontology, 2009

  • Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

    Journal of Cosmetic Dermatology, 2022

  • Topical application of a 2% cream containing combined fruit extracts for 56 days significantly reduced wrinkle depth by 11.5%, length by 10.07%, and area by 29.55% in 21 female subjects compared to a placebo.

    Clinical, Cosmetic and Investigational Dermatology, 2015

  • A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.

    Clinical, Cosmetic and Investigational Dermatology, 2015

  • A cosmetic formulation combining green tea and Ginkgo biloba extracts synergistically improved skin elasticity and skin barrier function in 48 volunteers compared to individual extracts.

    Journal of Drugs in Dermatology, 2014

  • Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.

    Cutis, 2004

  • Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.

    Journal of the American Academy of Dermatology, 1992

  • A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.

    The Journal of Clinical and Aesthetic Dermatology, 2020

  • Treatment with a combination of propylene glycol, ethanol, water, and shampoo was found effective, easy to use, and cosmetically attractive with no observed side effects in patients with dandruff.

    Cutis, 1988

  • A moisturizer containing glycerol and propylene glycol reduced transepidermal water loss, decreased epidermal thickness, increased stratum corneum thickness, and reduced dermal inflammatory infiltrate compared to untreated disrupted skin in six healthy beagle dogs.

    Veterinary Dermatology, 2020

Ingredients

Propylene Glycol, Water, Ginkgo Biloba Leaf Extract, Ascorbic Acid, Polysorbate 20, 2-Hexanediol, Polysorbate 80, Phenoxyethanol, Lactic Acid, Sodium Hydroxide, Ginkgo Biloba

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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Prices checked 5 Nov 2026

How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

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