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A+ 345 Relief Cream for dry skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

A+ 345 Relief Cream

Average

  • HighDry Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for dry skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate hydration for your dry skin, as glycerin and hyaluronic acid provide humectant benefits, though stronger barrier repair ingredients would enhance its effectiveness.
  • Niacinamide and panthenol offer soothing properties that complement the hydration, supporting overall skin comfort.
  • The product is safe for your dry skin, containing no harsh ingredients and including components that actively calm and moisturize.

How to apply

  • Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
  • Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
  • Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
  • Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
  • Avoid the sensitive eye area and do a patch test before your first use .

People Say

★4.4Overall rating based on 2.5k+ reviews

Based on a very large amount of data, this lightweight, gel-like cream is widely celebrated by users with oily, combination, and sensitive skin for its ability to soothe redness and fade post-acne marks without clogging pores. However, those with dry skin often find it insufficiently moisturizing, and a subset of users report breakouts or fungal acne triggers despite its soothing claims.

Highlights

  • Lightweight & fast-absorbing Mostly Mentioned
    • “absorbs in seconds”
    • “non-greasy finish”
    • “gel-cream texture”
    • “no sticky residue”
    • “feels like water”
  • Ideal for oily/combo skin Often Mentioned
    • “perfect for summer”
    • “doesn't clog pores”
    • “balances sebum”
    • “light enough for day”
    • “great under makeup”
  • Soothing & calming Often Mentioned
    • “calms redness instantly”
    • “cools irritated skin”
    • “soothes inflammation”
    • “reduced heat”
    • “helped sensitive barrier”
  • Fades acne marks Sometimes Noted
    • “lightened dark spots”
    • “helped with PIE”
    • “faded acne scars”
    • “cleared blemishes”
    • “evened skin tone”
  • Not moisturizing enough Sometimes Noted
    • “too light for dry skin”
    • “skin felt tight”
    • “need to layer”
    • “not occlusive enough”
    • “dried me out”
  • Caused breakouts Rarely Noted
    • “gave me whiteheads”
    • “caused closed comedones”
    • “broke me out”
    • “bad purging”
    • “clogged my pores”
  • Fungal acne trigger Rarely Noted
    • “triggered fungal acne”
    • “tiny itchy bumps”
    • “not FA safe”
    • “ruined skin texture”
    • “flare-up”
  • Texture/pilling issues Rarely Noted
    • “pills under sunscreen”
    • “tacky finish”
    • “films on face”
    • “separates makeup”
    • “rubbed off”

Sources: lovi.care, iherb.com, yesstyle.com, reddit.com, cosmetify.com, skinsort.com, and more

Questions and answers

How well does A+ 345 Relief Cream work for dry skin?

A+ 345 Relief Cream works moderately well for dry skin, providing basic hydration with glycerin and hyaluronic acid while helping soothe tightness with niacinamide and panthenol. Because it offers only moderate moisture, dry skin requires a product of this type to include stronger barrier repair ingredients and rich emollients to lock in hydration and fully support the skin barrier.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

Which ingredients make this cream a good fit for dry skin?

Glycerin, hyaluronic acid, niacinamide, and panthenol help make this cream a good fit by offering moderate hydration and soothing properties for dry skin. To fit dry skin even better, a product of this type needs stronger barrier repair ingredients.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2017

What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.

Journal of Cosmetic Dermatology, 2004Journal of Cosmetic Dermatology, 2026

What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.

Dermatology and Therapy, 2021Journal of Drugs in Dermatology, 2011

Where does it go in a skincare routine for dry skin?

Apply this moisturizing treatment as the last step in your evening routine, or right before sunscreen in the morning. Dry skin of this type needs richer barrier-repair ingredients to fully lock in moisture and keep skin feeling soft and comfortable.

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first and following with the cream to keep your skin comfortable. This type of skin needs a moisturizer with stronger barrier repair ingredients like ceramides to work best for dry skin.

How often should I use it?

You can use this moisturizing treatment twice a day as part of your routine to keep your dry skin soft and comfortable. Daily use helps maintain moisture levels and supports overall skin comfort, though dry skin generally benefits from richer barrier repair ingredients.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores or cause breakouts for dry skin, as it has a very low likelihood of causing such issues based on reviewer feedback. It contains gentle ingredients that help calm and moisturize without heavy oils.

Can I use it around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as it has a safe profile with no harsh ingredients. However, because dry skin needs stronger barrier repair ingredients to truly thrive, products of this type used there benefit from extra ceramides and rich oils.

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

    The British Journal of Dermatology, 2002

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical steroid withdrawal is driven by excess mitochondrial NAD+ metabolism that can be successfully targeted using complex I-inhibiting interventions such as metformin and berberine.

    The Journal of Investigative Dermatology, 2025

  • Topical steroid withdrawal presents as a distinct dermatopathology characterized by burning, flushing, thermodysregulation, and elevated mitochondrial NAD+ oxidation, which can be improved by targeting complex I with metformin or berberine.

    MedRxiv, 2024

  • Hydroxypropyl methylcellulose hydrogel formulations of berberine chloride-loaded escinosomes increased skin residence time and transdermal permeability while maintaining high safety and biocompatibility without skin irritation.

    International Journal of Biological Macromolecules, 2020

Ingredients

Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Niacinamide, Caprylic Capric Triglyceride, Polyglycerin-3, Panthenol, Polyglyceryl-10 Stearate, Hydrogenated Polydecene, Hydrogenated Poly C6-14 Olefin, Dicaprylyl Carbonate, Ammonium Acryloyldimethyltaurate Vp Copolymer, C14-22 Alcohols, Polymethylsilsesquioxane, C12-20 Alkyl Glucoside, Butylene Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Hyaluronic Acid, Coptis Japonica Root Extract, Houttuynia Cordata Extract, Oenothera Biennis Flower Extract, Beta-Glucan, Resveratrol, Gardenia Florida Fruit Extract, Lavandula Angustifolia Flower Extract Lavender Flower Extract, Opuntia Ficus-Indica Stem Extract, Hydrolyzed Hyaluronic Acid, Centella Asiatica Leaf Extract, Phenoxyethanol, Hibiscus Sabdariffa Flower Extract, Tocopherol, Corallina Officinalis Extract, Ceramide Np

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play