Avène Cleanance Comedomed Anti-Blemish Concentrate for oily skin
Avène Thermal Spring Water
Silybum Marianum Fruit Extract
Glycerin
Isopropyl Alcohol
SilicaAverage
- SuperiorOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your oily skin is provided by isopropyl alcohol and silybum marianum fruit extract, which offer seboregulation and mild astringent effects to combat oily shine.
- The formula offers moderate treatment for blemishes due to silybum marianum fruit extract concentrations that help reduce acne lesions, providing general skincare benefits like hydration and cleansing.
- The safety profile is excellent, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
People Say
★4.3Overall rating based on 4.0k+ reviewsBased on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs super fast”
- “watery gel texture”
- “non-greasy finish”
- “leaves skin matte”
Reduces blemishes Mostly Mentioned
- “significant reduction in blemishes”
- “keeps whiteheads at bay”
- “cleared my hormonal acne”
- “pores look smaller”
Strong alcohol scent Mostly Mentioned
- “powerful alcohol smell”
- “smells like hand sanitizer”
- “strong chemical odor”
- “scent is overpowering”
Controls oil Often Mentioned
- “mattifies the skin”
- “controls excess sebum”
- “less oily during the day”
- “shine-free complexion”
Prevents breakouts Sometimes Noted
- “limits recurrence of spots”
- “stops pimples forming”
- “prevented PMS breakouts”
- “keeps skin clear long-term”
Drying or peeling Sometimes Noted
- “made my face peel”
- “caused dry patches”
- “drying around the nose”
- “not moisturizing enough alone”
Initial skin purging Rarely Noted
- “sped up the purge”
- “broke out more at first”
- “worsened acne before improving”
- “caused small bumps initially”
Stinging sensation Rarely Noted
- “slight burning upon application”
- “stings sensitive areas”
- “tingling sensation”
- “irritated broken skin”
Sources: lovi.care, dermstore.com, aveneusa.com, beautycrew.com.au, hometesterclub.com, reddit.com, and more
Questions and answers
How well does Avène Cleanance Comedomed work for oily skin?
This treatment works moderately well for oily skin by helping reduce shine and blemishes, though other products fit this skin type better. An ideal product for oily skin needs ingredients like niacinamide and zinc PCA to control excess oil and pores, along with soothing extracts and lightweight hydrators to keep the skin comfortable without clogging it.
Which ingredients make this treatment a good fit for oily skin?
Isopropyl alcohol and silybum marianum fruit extract make this treatment a good fit for oily skin by helping control oily shine and reduce blemishes. To fit oily skin even better, products of this type need ingredients like niacinamide, zinc PCA, and ferulic acid to manage oil and pores, along with soothing and hydrating ingredients like ceramides and panthenol.
What does Avène Thermal Spring Water do for oily skin?
Avène Thermal Spring Water helps calm and soothe the skin while reducing redness and sensitivity. It has a very gentle profile that is unlikely to clog pores, making it comfortable for oily skin types.
Journal of the European Academy of Dermatology and Venereology, 2020
What does Milk Thistle Fruit Extract do for oily skin?
Milk thistle fruit extract helps calm oily and acne-prone skin while improving texture and keeping irritation low. It is well-tolerated and may help reduce blemishes and redness when used regularly in your skincare routine.
Journal of Cosmetic Dermatology, 2023Current Pharmaceutical Biotechnology, 2025
Where does this treatment go in a skincare routine for oily skin?
This treatment goes in the evening routine after cleansing and before moisturizing, though some treatments may also be used in the morning or twice a day. Oily skin works best with products that offer oil control, blemish-reducing ingredients, and lightweight hydration.
Can I use this treatment with retinol, and in what order?
This treatment works for your oily skin, though other products fit it better, and you should use it before your moisturizer while keeping retinol in a separate step or night to avoid irritation. Oily skin needs targeted ingredients that balance oil and clear blemishes while keeping the skin calm and hydrated.
How often should I use this treatment?
You can use this treatment in your evening routine, applying it once a day. Oily skin needs lightweight hydrating ingredients and oil-balancing extracts to keep shine under control without feeling heavy.
Can this treatment clog pores, cause breakouts or purging for oily skin?
This treatment is unlikely to clog pores, but initial skin purging is a low possibility for oily skin. Reviewers sometimes note drying or peeling, while an oily skin product of this type needs ingredients that balance oil and hydrate without heavy feel.
Is this treatment fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (isopropyl alcohol).
What the research says
Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.
Life, 2023Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.
The Medical Journal of Malaysia, 2024A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.
International Journal of Cosmetic Science, 2025Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.
Journal of Cosmetic Dermatology, 2024Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.
Journal of Cosmetic Dermatology, 2023Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.
Journal of Cutaneous Medicine and Surgery, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers.
The Journal of Bone and Joint Surgery. American Volume, 2005Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy.
Cureus, 2024Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis.
Skinmed, 2016A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities.
Antioxidants, 2020Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers.
European Journal of Pharmaceutical Sciences, 2017Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro.
Experimental Dermatology, 2008
Ingredients
Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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