Avène Cleanance Comedomed Anti-Blemish Concentrate for dry skin
Avène Thermal Spring Water
Silybum Marianum Fruit Extract
Glycerin
Isopropyl Alcohol
SilicaCaution
- LowDry Skin Fit
- AverageEffectiveness
- RiskySafety
A poor match for dry skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate exfoliation for your dry skin due to the presence of isopropyl alcohol and silica, which can be drying and may not adequately support your skin barrier.
- The formula includes isopropyl alcohol and silybum marianum fruit extract to help reduce blemishes, providing moderate treatment for acne-prone skin.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.3Overall rating based on 4.0k+ reviewsBased on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs super fast”
- “watery gel texture”
- “non-greasy finish”
- “leaves skin matte”
Reduces blemishes Mostly Mentioned
- “significant reduction in blemishes”
- “keeps whiteheads at bay”
- “cleared my hormonal acne”
- “pores look smaller”
Strong alcohol scent Mostly Mentioned
- “powerful alcohol smell”
- “smells like hand sanitizer”
- “strong chemical odor”
- “scent is overpowering”
Controls oil Often Mentioned
- “mattifies the skin”
- “controls excess sebum”
- “less oily during the day”
- “shine-free complexion”
Prevents breakouts Sometimes Noted
- “limits recurrence of spots”
- “stops pimples forming”
- “prevented PMS breakouts”
- “keeps skin clear long-term”
Drying or peeling Sometimes Noted
- “made my face peel”
- “caused dry patches”
- “drying around the nose”
- “not moisturizing enough alone”
Initial skin purging Rarely Noted
- “sped up the purge”
- “broke out more at first”
- “worsened acne before improving”
- “caused small bumps initially”
Stinging sensation Rarely Noted
- “slight burning upon application”
- “stings sensitive areas”
- “tingling sensation”
- “irritated broken skin”
Sources: lovi.care, dermstore.com, aveneusa.com, beautycrew.com.au, hometesterclub.com, reddit.com, and more
Questions and answers
Why does Lovi advise caution with Cleanance Comedomed Anti-Blemish Concentrate for dry skin?
This treatment offers moderate exfoliation that can be drying on dry skin and may not adequately support your skin barrier. A product for this skin needs soothing ingredients that provide significant hydration and support skin health without any risk of irritation, such as propolis, niacinamide, ceramides, vitamin C, bifida fermentation, and peptides.
Which ingredients make this treatment a poor fit for dry skin?
Isopropyl alcohol and silica make this treatment a poor fit because they offer moderate exfoliation that can be drying and may not adequately support your dry skin barrier. To suit dry skin, a treatment of this type needs soothing ingredients, ceramides, niacinamide, or peptides that provide deep hydration and support skin health without any risk of irritation.
What does Avène Thermal Spring Water do for dry skin?
Avene Thermal Spring Water helps calm dry skin by reducing redness and soothing irritation. Regular use may also improve skin comfort and reduce the feeling of tightness.
The Medical Journal of Malaysia, 2024Journal of the European Academy of Dermatology and Venereology, 2020
What does Milk Thistle Fruit Extract do for dry skin?
Milk thistle fruit extract helps soothe dry skin by calming redness and locking in moisture to keep your face feeling soft and smooth. It may also help protect against daily irritation and dryness with its antioxidant properties.
Journal of Cosmetic Dermatology, 2008Journal of Drugs in Dermatology, 2013
Where does this treatment go in a skincare routine for dry skin?
This treatment goes in the evening routine after cleansing and before moisturizing, though it requires caution on dry skin because it can be drying and may not adequately support your skin barrier. A product of this type for dry skin needs gentle, hydrating ingredients and barrier-supporting components like glycerin and soothing plant extracts.
Can I use this treatment with retinol, and in what order?
Using this treatment with retinol on dry skin is not recommended because both products can dry out your skin and may harm your skin barrier. Instead, dry skin needs gentle, hydrating ingredients and rich moisturizers that soothe and protect the skin barrier while managing blemishes.
How often should I use this treatment?
This treatment is a poor fit for your dry skin, so you should use it only once a week to see how your skin tolerates it. The drying ingredients in this formula may cause irritation and do not adequately support your skin barrier. A product for dry skin needs gentle ingredients like glycerin and soothing plant extracts to keep your skin soft and calm.
Can this treatment clog pores, cause breakouts or purging for dry skin?
This treatment is unlikely to clog pores, but it may cause mild peeling or initial purging on dry skin because it contains isopropyl alcohol and silica. Dry skin needs gentle hydration and soothing ingredients like ceramides or hyaluronic acid to stay smooth and comfortable without drying out.
Is this treatment fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (isopropyl alcohol).
What the research says
Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.
Life, 2023Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.
The Medical Journal of Malaysia, 2024A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.
International Journal of Cosmetic Science, 2025Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.
Journal of Cosmetic Dermatology, 2024Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.
Journal of Cosmetic Dermatology, 2023Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.
Journal of Cutaneous Medicine and Surgery, 2024A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers.
The Journal of Bone and Joint Surgery. American Volume, 2005Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy.
Cureus, 2024Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis.
Skinmed, 2016A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities.
Antioxidants, 2020Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers.
European Journal of Pharmaceutical Sciences, 2017Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro.
Experimental Dermatology, 2008
Ingredients
Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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