Avène Cleanance Comedomed Anti-Blemish Concentrate for dry sensitive skin
Avène Thermal Spring Water
Silybum Marianum Fruit Extract
Glycerin
Isopropyl Alcohol
SilicaLow
- LowDry Skin Fit
- HighEffectiveness
- RiskySafety
A weak match for dry sensitive skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate treatment for your acne-prone skin as isopropyl alcohol and silybum marianum fruit extract help reduce blemishes, though the isopropyl alcohol may worsen your dry and sensitive skin.
- Glycerin provides some hydration for your dry or flaky skin, but the formula lacks sufficient emollient ingredients to adequately support your skin barrier.
How to apply
- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
People Say
★4.3Overall rating based on 4.0k+ reviewsBased on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.
Highlights
Lightweight & fast-absorbing Mostly Mentioned
- “absorbs super fast”
- “watery gel texture”
- “non-greasy finish”
- “leaves skin matte”
Reduces blemishes Mostly Mentioned
- “significant reduction in blemishes”
- “keeps whiteheads at bay”
- “cleared my hormonal acne”
- “pores look smaller”
Strong alcohol scent Mostly Mentioned
- “powerful alcohol smell”
- “smells like hand sanitizer”
- “strong chemical odor”
- “scent is overpowering”
Controls oil Often Mentioned
- “mattifies the skin”
- “controls excess sebum”
- “less oily during the day”
- “shine-free complexion”
Prevents breakouts Sometimes Noted
- “limits recurrence of spots”
- “stops pimples forming”
- “prevented PMS breakouts”
- “keeps skin clear long-term”
Drying or peeling Sometimes Noted
- “made my face peel”
- “caused dry patches”
- “drying around the nose”
- “not moisturizing enough alone”
Initial skin purging Rarely Noted
- “sped up the purge”
- “broke out more at first”
- “worsened acne before improving”
- “caused small bumps initially”
Stinging sensation Rarely Noted
- “slight burning upon application”
- “stings sensitive areas”
- “tingling sensation”
- “irritated broken skin”
Sources: lovi.care, dermstore.com, aveneusa.com, beautycrew.com.au, hometesterclub.com, reddit.com, and more
Questions and answers
Why is Avène Cleanance Comedomed Anti-Blemish Concentrate a weak match for dry sensitive skin?
This treatment is a weak match because the isopropyl alcohol in it may worsen your dry and sensitive skin, and it lacks sufficient rich moisturizing and nourishing ingredients to properly support your skin barrier. A product of this type needs effective hydrating and protecting ingredients like ceramides and vitamins to keep dry skin calm, soft, and smooth without any risk of irritation.
Which ingredients make this treatment a poor fit for dry sensitive skin?
Isopropyl alcohol makes this treatment a poor fit because it may worsen dry and sensitive skin. A product for this skin needs rich hydrating and nourishing ingredients, such as ceramides and multiple forms of vitamin C, to support the skin barrier without irritation.
What does Avène Thermal Spring Water do for dry sensitive skin?
Avène Thermal Spring Water helps calm red, irritated skin and reduces stinging and burning while keeping it soft and comfortable. It has a very safe profile for sensitive skin and supports moisture balance to relieve dryness.
The Medical Journal of Malaysia, 2024Journal of the European Academy of Dermatology and Venereology, 2020
What does Milk Thistle Fruit Extract do for dry sensitive skin?
Milk thistle fruit extract helps calm dry sensitive skin by easing redness and irritation. It supports the skin barrier with soothing properties that are gentle and well tolerated.
Where does this treatment go in a skincare routine for dry sensitive skin?
This treatment goes in the evening routine for dry sensitive skin, applied after a soothing toner and before a moisturizer. Because this product is a weak match for your skin, a product of this type needs rich moisturizing ingredients and skin-softening oils to keep dry skin calm and hydrated.
Can I use this treatment with retinol, and in what order?
This treatment is a weak match for your dry and sensitive skin because its alcohol content may worsen dryness and irritation. A product of this type needs gentle blemish-reducing ingredients paired with rich, soothing moisturizers and barrier-protecting oils to keep dry skin comfortable.
How often should I use this treatment?
This product is a weak match for your dry and sensitive skin because it contains drying ingredients that may worsen irritation and lacks enough softening components to protect your skin barrier. To safely treat your skin type, a product of this type needs rich moisturizing ingredients and barrier-protecting components like ceramides or plant oils.
Can this treatment clog pores, cause breakouts or purging for dry sensitive skin?
This treatment is unlikely to clog pores or cause breakouts, but it may cause drying or peeling on dry and sensitive skin because it contains isopropyl alcohol. A product for this skin needs rich moisturizing ingredients and protective oils to support the skin barrier while targeting blemishes.
Is this treatment fragrance-free and alcohol-free?
It has no fragrance and contains drying alcohol (isopropyl alcohol).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.
Life, 2023Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.
The Medical Journal of Malaysia, 2024A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.
International Journal of Cosmetic Science, 2025Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.
Journal of Cosmetic Dermatology, 2024Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.
Journal of Cosmetic Dermatology, 2023Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.
Journal of Cutaneous Medicine and Surgery, 2024The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers.
The Journal of Bone and Joint Surgery. American Volume, 2005Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy.
Cureus, 2024Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis.
Skinmed, 2016A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities.
Antioxidants, 2020Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers.
European Journal of Pharmaceutical Sciences, 2017Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro.
Experimental Dermatology, 2008
Why other serums fit dry sensitive skin better
In 50 participants with sensitive skin, a Ceramide NP C15-containing emollient improved skin barrier function with a significant reduction in transepidermal water loss and induced modest changes in skin microbiota compared to the vehicle.
Skin Pharmacology and Physiology, 2026Topical and oral vitamin E exhibited antitumorigenic, photoprotective, and skin barrier stabilizing properties in human skin.
Molecular Aspects of Medicine, 2007
Ingredients
Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
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Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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