Anua Heartleaf 77% Clear Pad for mature skin

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Questions and answers

What the research says

• A hyperoside-enriched fraction of Houttuynia cordata Thunb. inhibited UVB-induced oxidative stress, inflammation, and collagen degradation in human dermal fibroblasts by regulating the MAPK signaling pathway.

  Plants, 2021

• Houttuynia cordata extract containing hyperoside and quercitrin protected human HaCaT keratinocytes from UVB-induced cell damage, apoptosis, oxidative stress, and inflammation by modulating MAPKs and Akt signaling pathways.

  Antioxidants, 2022

• Fermented Houttuynia cordata extracts reduced oxidative stress, inflammation factors, and inflammatory gene expression while increasing keratin-1 gene expression in H2O2 and UVA-treated human skin keratinocytes more effectively than unfermented extracts.

  Applied Biochemistry and Biotechnology, 2023

• Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine.

  Skin Research and Technology, 2003

• Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream.

  Clinical, Cosmetic and Investigational Dermatology, 2016

• Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution.

  Molecules, 2019

• Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration.

  Gels, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events.

  Journal of Oral Rehabilitation, 2007

• A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers.

  Molecules, 2024

• Mixed surfactant systems of sodium dodecyl sulfate and dimethyl dodecyl amido betaine significantly reduce acute skin irritation potential in human volunteers compared with the individual surfactants, demonstrating that irritation potential cannot be predicted by simple summation.

  Food and Chemical Toxicology, 1998

Ingredients

Houttuynia Cordata Extract, Water, Gluconolactone, Propanediol, Tromethamine, Butylene Glycol, 1,2-Hexanediol, Betaine, Ammonium Acryloyldimethyltaurate Vp Copolymer, Ulmus Davidiana Root Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Oenothera Biennis Flower Extract, Camellia Sinensis Leaf Extract, Coix Lacryma-Jobi Seed Extract, Portulaca Oleracea Extract, Centella Asiatica Extract, Madecassoside, Asiatic Acid, Asiaticoside, Madecassic Acid, Sodium Phytate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.