SKIN1004 Madagascar Centella Hyalu-Cica Cloudy Mist for skin with dark spots

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Questions and answers

What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Nanoemulsion incorporating Cordyceps militaris water extract enhanced chemical stability, showed no cytotoxicity or skin irritation, and successfully delivered the extract into the skin layer.

  Nanomaterials, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

• Cordyceps sinensis mycelium hydroethanolic extract increased sirtuin expression, NAD+ synthesis, ATP production, collagen synthesis, and reduced ROS and wrinkles in in vitro assays and human subjects compared to controls.

  International Journal of Molecular Sciences, 2024

• Topical cream containing 0.2% Cordyceps militaris polysaccharide extract was safe and achieved over 70% overall preference in 20 female volunteers.

  Fungal Biology and Biotechnology, 2023

• A cordycepin/chitosan hydrogel dressing served as a quicker re-epithelization of skin wounds and an apparent increasing collagen deposition compared with chitosan hydrogels in vivo.

  International Journal of Biological Macromolecules, 2019

Ingredients

Camellia Sinensis Leaf Water, Water, 1,2-Hexanediol, Isopentyldiol, Centella Asiatica Extract, Cordyceps Militaris Extract, Hibiscus Esculentus Fruit Extract, Butylene Glycol, Methylpropanediol, Betaine, Xylitol, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Polyglyceryl-10 Oleate, Polyglyceryl-10 Myristate, Pentylene Glycol, Polyglyceryl-6 Dioleate, Pyrus Communis Fruit Extract, Adenosine, Rosa Damascena Flower Water, Polyglyceryl-4 Laurate, Ethylhexylglycerin, Cucumis Melo Fruit Extract, Citric Acid, Iris Florentina Root Extract, Sodium Phytate, Hedera Helix Stem Extract Leaf, Polyglutamic Acid, Galactomyces Ferment Filtrate, Artemisia Princeps Leaf Extract, Glycerin, Caprylic Capric Triglyceride, Hydrogenated Lecithin, Ceramide Np

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.