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A+ 345 Relief Cream for mature skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

A+ 345 Relief Cream

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for mature skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate moisturizing benefits for your normal skin due to glycerin and hyaluronic acid, which hydrate and plump effectively, but does not specifically target your wrinkles and fine lines.
  • Panthenol and various botanical extracts provide general soothing and supportive skincare, enhancing overall skin comfort.
  • The product is safe for your normal skin, with no reported irritation risks from harsh or prohibited ingredients.

How to apply

  • Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
  • Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
  • Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
  • Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
  • Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.

People Say

★4.4Overall rating based on 2.5k+ reviews

Based on a very large amount of data, this lightweight, gel-like cream is widely celebrated by users with oily, combination, and sensitive skin for its ability to soothe redness and fade post-acne marks without clogging pores. However, those with dry skin often find it insufficiently moisturizing, and a subset of users report breakouts or fungal acne triggers despite its soothing claims.

Highlights

  • Lightweight & fast-absorbing Mostly Mentioned
    • “absorbs in seconds”
    • “non-greasy finish”
    • “gel-cream texture”
    • “no sticky residue”
    • “feels like water”
  • Ideal for oily/combo skin Often Mentioned
    • “perfect for summer”
    • “doesn't clog pores”
    • “balances sebum”
    • “light enough for day”
    • “great under makeup”
  • Soothing & calming Often Mentioned
    • “calms redness instantly”
    • “cools irritated skin”
    • “soothes inflammation”
    • “reduced heat”
    • “helped sensitive barrier”
  • Fades acne marks Sometimes Noted
    • “lightened dark spots”
    • “helped with PIE”
    • “faded acne scars”
    • “cleared blemishes”
    • “evened skin tone”
  • Not moisturizing enough Sometimes Noted
    • “too light for dry skin”
    • “skin felt tight”
    • “need to layer”
    • “not occlusive enough”
    • “dried me out”
  • Caused breakouts Rarely Noted
    • “gave me whiteheads”
    • “caused closed comedones”
    • “broke me out”
    • “bad purging”
    • “clogged my pores”
  • Fungal acne trigger Rarely Noted
    • “triggered fungal acne”
    • “tiny itchy bumps”
    • “not FA safe”
    • “ruined skin texture”
    • “flare-up”
  • Texture/pilling issues Rarely Noted
    • “pills under sunscreen”
    • “tacky finish”
    • “films on face”
    • “separates makeup”
    • “rubbed off”

Sources: lovi.care, iherb.com, yesstyle.com, reddit.com, cosmetify.com, skinsort.com, and more

Questions and answers

How well does A+ 345 Relief Cream work for mature skin?

A+ 345 Relief Cream is an average fit for mature skin because, while it hydrates and plumps effectively, it does not specifically target wrinkles and fine lines. To better support mature skin, a moisturizing treatment needs potent anti-aging ingredients like peptides and antioxidants alongside rich nourishing components.

Clinical, Cosmetic and Investigational Dermatology, 2017American Journal of Clinical Dermatology, 2002

Which ingredients make this cream a good fit for mature skin?

Niacinamide, hyaluronic acid, and glycerin make this cream a good fit by hydrating and plumping mature skin. However, a product for this skin also needs potent anti-aging ingredients like peptides and antioxidants to address wrinkles and fine lines.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.

Antioxidants, 2021Journal of Cosmetic Dermatology, 2004

What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.

Journal of Drugs in Dermatology, 2011Skin Research and Technology, 2024

Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment is used as a moisturizer in your morning routine and as the final step in your evening and weekly routines. Mature skin also needs targeted ingredients like peptides or retinoids to help smooth wrinkles and fine lines.

The Journal of Dermatological Treatment, 2022Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it after your retinol treatment in the evening routine to help soothe and comfort the skin. Mature skin needs products with ingredients like retinol, peptides, and antioxidants that target wrinkles and firm the skin.

How often should I use this cream?

You can use this moisturizing treatment twice a day to keep your skin hydrated and comfortable. Regular daily use of a moisturizer like this helps maintain skin moisture and barrier function.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts or clog pores on mature skin, as it has a low risk of causing breakouts and no harsh ingredients that could irritate. To care for mature skin properly, a product of this type also needs ingredients that actively smooth wrinkles and firm up the skin.

Can I use this cream around the eyes or on my body?

You can use this cream on your body or around the eyes, as it has a safe profile with no harsh ingredients. However, because mature skin needs targeted ingredients like potent anti-wrinkle peptides and firming actives to properly smooth lines and wrinkles around the eyes, this average-fitting moisturizing treatment may not be enough for aging concerns.

Surgical and Radiologic Anatomy, 2002

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.

    Journal of Cosmetic Dermatology, 2025

  • Hydroxypropyl methylcellulose hydrogel formulations of berberine chloride-loaded escinosomes increased skin residence time and transdermal permeability while maintaining high safety and biocompatibility without skin irritation.

    International Journal of Biological Macromolecules, 2020

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

  • Topical steroid withdrawal is driven by excess mitochondrial NAD+ metabolism that can be successfully targeted using complex I-inhibiting interventions such as metformin and berberine.

    The Journal of Investigative Dermatology, 2025

  • Topical steroid withdrawal presents as a distinct dermatopathology characterized by burning, flushing, thermodysregulation, and elevated mitochondrial NAD+ oxidation, which can be improved by targeting complex I with metformin or berberine.

    MedRxiv, 2024

  • A carboxymethyl cellulose-based hydrogel film loaded with berberine reduced keratinocyte hyperproliferation by 25% and controlled oxidative stress and inflammation markers in vitro.

    Carbohydrate Polymers, 2022

Why other moisturizers fit mature skin better

  • Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

    International Journal of Medical Sciences, 2021

  • Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement.

    Nanomaterials, 2024

  • Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants.

    Journal of Cosmetic Dermatology, 2026

Ingredients

Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Niacinamide, Caprylic Capric Triglyceride, Polyglycerin-3, Panthenol, Polyglyceryl-10 Stearate, Hydrogenated Polydecene, Hydrogenated Poly C6-14 Olefin, Dicaprylyl Carbonate, Ammonium Acryloyldimethyltaurate Vp Copolymer, C14-22 Alcohols, Polymethylsilsesquioxane, C12-20 Alkyl Glucoside, Butylene Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Hyaluronic Acid, Coptis Japonica Root Extract, Houttuynia Cordata Extract, Oenothera Biennis Flower Extract, Beta-Glucan, Resveratrol, Gardenia Florida Fruit Extract, Lavandula Angustifolia Flower Extract Lavender Flower Extract, Opuntia Ficus-Indica Stem Extract, Hydrolyzed Hyaluronic Acid, Centella Asiatica Leaf Extract, Phenoxyethanol, Hibiscus Sabdariffa Flower Extract, Tocopherol, Corallina Officinalis Extract, Ceramide Np

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play