SKIN1004 Madagascar Centella Tea-Trica Relief Ampoule for skin with dark spots

How to apply

Questions and answers

What the research says

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Chitosan-based hydrogels loaded with asiaticoside-rich Centella asiatica extract achieved controlled drug release, skin permeability, antimicrobial activity, and synergistic wound healing effects in an in vitro model.

  International Journal of Molecular Sciences, 2023

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Lactobacillus-fermented Chamaecyparis obtusa reduced inflammatory acne lesions by 65.3% compared to 38.2% with tea tree oil in 34 patients over 8 weeks, demonstrating superior efficacy, faster onset, and safety.

  Dermatology, 2014

• Hinokitiol treatment attenuates LPS-induced proinflammatory factors, NF-kappaB activation, and cell migration in primary human keratinocytes via Sirt1 histone deacetylase activation.

  The Journal of Investigative Dermatology, 2017

• A lipid mixture representing major components of Chamaecyparis obtusa extract up-regulated HBD-3 and LL-37, exhibited bactericidal effects against Staphylococcus aureus and Streptococcus pyogenes, protected against keratinocyte cell death, and accelerated skin wound healing and healing of S. aureus-superinfected wounds in an animal model.

  The Journal of Investigative Dermatology, 2018

• Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport.

  Biomaterials Advances, 2022

• A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides.

  Medicina Cutanea Ibero-latino-americana, 1986

• Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models.

  Metabolites, 2021

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

Ingredients

Centella Asiatica Extract, Chamaecyparis Obtusa Water, Melaleuca Alternifolia Tree Leaf Water, Pinus Palustris Leaf Extract, Glycerin, Butylene Glycol, Methyl Gluceth-20, Dipropylene Glycol, Glycereth-26, 1,2-Hexanediol, Water, Hydroxyacetophenone, Ammonium Acryloyldimethyl Taurate Vp Copolymer, Propanediol, Polyglyceryl-10 Laurate, Ethylhexylglycerin, Pentylene Glycol, Caprylyl Glycol, Disodium Edta, Melaleuca Alternifolia Oil Leaf, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.