NIOD Modulating Glucosides for mature skin
Glucosides
Squalane
Superoxide Dismutase
Epigallocatechin Gallatyl Glucoside
Palmitoyl Tripeptide-8
High
- HighNormal Skin Fit
- HighEffectiveness
- HighSafety
A great choice for mature skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent for your normal skin, this formula leverages Palmitoyl Tripeptide-8 and Epigallocatechin Gallatyl Glucoside to effectively target wrinkles and fine lines while providing soothing and anti-redness benefits.
- The inclusion of Bisabolol and Tasmannia Lanceolata Leaf Extract further enhances its calming properties, making it a well-rounded choice for your skin concerns.
- The product is safe for your skin, with no reported risks of irritation due to its gentle formulation and absence of harsh ingredients.
How to apply
- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
People Say
★4.8Overall rating based on 400+ reviewsThis serum is highly praised for its ability to calm sensitive, reactive, and irritated skin, with users frequently reporting significant improvements in redness, stinging, and compromised skin barriers. It is a popular choice for those recovering from aesthetic treatments or harsh active ingredients. Some users with normal skin may find the benefits less noticeable or the texture slightly heavy.
Highlights
Calms sensitive skin Mostly Mentioned
- “Like medicine to irritated skin.”
- “Great for sensitive, reactive skin.”
- “Helps quiet sensations of stinging and itching.”
Reduces skin redness Often Mentioned
- “Visibly reduced redness for a more even tone.”
- “Calms redness and stinging.”
- “It really did wonders in soothing skin and reducing redness.”
Buffers active irritation Sometimes Noted
- “Helps minimise the side effects of retinoids.”
- “Buffers retinoid/acid irritation.”
- “Reason my skin had been so calm while I was on Roaccutane.”
Strengthens skin barrier Sometimes Noted
- “Saved my skin barrier from beyond hope.”
- “Strengthens skin barrier integrity over time.”
- “Especially helpful when my barrier is compromised.”
Inconvenient packaging Sometimes Noted
- “Dropper bottle is messy to use.”
- “Not my favorite type of packaging.”
- “Why doesn't it come with a pump?”
Subtle for normal skin Sometimes Noted
- “If you have normal skin, benefits may not be apparent.”
- “I did not notice any improvement.”
Can cause breakouts Rarely Noted
- “It broke me out almost instantly.”
- “Heavy going on my face.”
Unappealing scent Rarely Noted
- “Strong nutty scent.”
- “A bit like paint.”
- “Has a bit of a medicinal smell.”
Sources: lovi.care, niod.com, skinsort.com, dermapproved.com, drrachelho.com, daniellesbeautyblog.com, and more
Questions and answers
What makes Modulating Glucosides a great fit for mature skin?
This treatment is a great fit because it uses Palmitoyl Tripeptide-8 and Epigallocatechin Gallatyl Glucoside to target wrinkles and fine lines while keeping your skin calm and smooth. It also includes Bisabolol and Tasmannia Lanceolata Leaf Extract to soothe irritation, and it is unlikely to cause any negative reactions on your skin.
Which ingredients make it a good serum for mature skin?
This formula targets fine lines and wrinkles while keeping skin calm through ingredients like Palmitoyl Tripeptide-8 and Epigallocatechin Gallatyl Glucoside. It also includes Bisabolol and Tasmannia Lanceolata Leaf Extract to soothe the skin with a gentle formula that is unlikely to cause irritation.
What do Glucosides do for mature skin?
Glucosides help protect mature skin from daily oxidative stress and environmental damage while supporting a smoother, brighter look. Using these antioxidant derivatives is unlikely to irritate the skin and helps maintain a healthy glow over time.
International Journal of Cosmetic Science, 2021International Journal of Biological Macromolecules, 2025
What does Squalane do for mature skin?
Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Journal of Nanobiotechnology, 2025Journal of Nanoscience and Nanotechnology, 2010
Where does it go in a skincare routine for mature skin?
This treatment goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
How often should I use it?
This treatment is used in the evening as part of your routine. It is a great fit for mature skin to help smooth fine lines and calm redness, and it is unlikely to cause irritation.
Can Modulating Glucosides clog pores, cause breakouts or purging for mature skin?
This product is unlikely to clog pores or cause breakouts for mature skin, thanks to its gentle formulation without harsh ingredients. Reviewers occasionally mention breakouts as a minor issue, but the overall safety profile supports a very low risk of irritation.
Is it fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (benzyl alcohol).
What the research says
Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls.
International Journal of Cosmetic Science, 2004Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable.
European Journal of Pharmaceutics and Biopharmaceutics, 2007Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.
Journal of Clinical and Diagnostic Research, 2017Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.
Experimental Dermatology, 2009An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.
Clinical, Cosmetic and Investigational Dermatology, 2019
Ingredients
Water, Squalane, Isodecyl Neopentanoate, Glycerin, Caprylic Capric Triglyceride, Pentylene Glycol, Propanediol, Hexyldecanol, Bisabolol, Butylene Glycol, Epigallocatechin Gallatyl Glucoside, Rosmarinyl Glucoside, Caffeyl Glucoside, Gallyl Glucoside, Tetrasodium Tetracarboxymethyl Naringeninchalcone, Hydroxymethoxyphenyl Decanone, 4-T-Butylcyclohexanol, Cetylhydroxyproline Palmitamide, Hydroxyphenyl Propamidobenzoic Acid, Palmitoyl Tripeptide-8, Superoxide Dismutase, Sodium Pca, Pca, Arginine, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Aspartic Acid, Sodium Lactate, Mirabilis Jalapa Callus Extract, Tasmannia Lanceolata Leaf Extract Fruit, Zingiber Officinale Root Extract, Curculigo Orchioides Root Extract, Isochrysis Galbana Extract, Brassica Campestris Sterols, Stearic Acid, Dextran, Isoceteth-20, Polyacrylate Crosspolymer-6, Xanthan Gum, Tocopherol, Propyl Gallate, Tromethamine, Dehydroacetic Acid, 1,2-Hexanediol, Benzyl Alcohol, Phenoxyethanol, Caprylyl Glycol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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