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Superoxide dismutase

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Superoxide dismutase

Superoxide dismutase protects the skin by visibly calming redness, reducing UV-induced irritation, and lowering oxidative lipid stress for a healthier barrier. This powerhouse ingredient suits both dry skin and oily skin types, and it is most commonly found in lightweight serums. You can easily add it to your daily routine, but be sure to keep it apart from bio-placenta peptides, hexapeptide, and acetyl hexapeptide-3.

European Journal of Pharmaceutics and Biopharmaceutics, 2016International Journal of Cosmetic Science, 2004

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Superoxide dismutase serums

What reviewers say about popular superoxide dismutase products

The highlight reviewers mention most for each popular superoxide dismutase product on Lovi.

Other superoxide dismutase products

Superoxide dismutase for dry skin

Superoxide dismutase for oily skin

Superoxide dismutase for combination skin

Superoxide dismutase for sensitive skin

Superoxide dismutase for acne-prone skin

What to combine superoxide dismutase with

IngredientTogetherHow to use them
Bio-placenta peptides Keep apart Use them at different times of day, applying the peptides in the morning and superoxide dismutase at night, because they clash and cancel each other out. Superoxide dismutase and bio-placenta peptides
Hexapeptide Keep apart Use them at different times of day, applying hexapeptide in the morning and superoxide dismutase at night, because their active structures clash. Superoxide dismutase and hexapeptide
Acetyl hexapeptide-3 Keep apart Use them at different times of day, applying the peptide first and the enzyme later, because they cancel each other out. Superoxide dismutase and acetyl hexapeptide-3
Collagen peptide Keep apart Use them at different times of day, applying the peptide first, because enzymes can break down peptides. Superoxide dismutase and collagen peptide
Copper peptide Keep apart Use them at different times of day, applying copper peptide in the morning and superoxide dismutase at night. Superoxide dismutase and copper peptide
Hexapeptide-9 Keep apart Use them at different times of day, applying superoxide dismutase first and hexapeptide-9 later, because mixing them breaks down the active ingredients. Superoxide dismutase and hexapeptide-9
Peptide-rich plasma Keep apart Use them at different times of day, applying the peptide product in the morning and superoxide dismutase at night. Superoxide dismutase and peptide-rich plasma
Triple peptide blend Keep apart Use them at different times of day, applying the peptide blend first and the enzyme later, because they cancel each other out. Superoxide dismutase and triple peptide blend
Palmitoyl pentapeptide-4 Keep apart Use them at different times of day, applying superoxide dismutase first and palmitoyl pentapeptide-4 later, to prevent the enzyme from breaking down the peptide. Superoxide dismutase and palmitoyl pentapeptide-4
Palmitoyl tripeptide-1 Keep apart Use superoxide dismutase and palmitoyl tripeptide-1 at different times of day, applying the enzyme product in the morning and the peptide at night. Superoxide dismutase and palmitoyl tripeptide-1

From the ingredient rules behind the "Works well with" and "Don't mix with" notes on every product in the Lovi app.

Questions and answers

What does superoxide dismutase do for the skin?

Superoxide dismutase helps defend the skin against environmental damage by reducing UV-induced redness and minimizing lipid peroxides on the skin surface.

European Journal of Pharmaceutics and Biopharmaceutics, 2016International Journal of Cosmetic Science, 2004

How do you use superoxide dismutase?

You can use superoxide dismutase at night to help protect your skin, but you should keep it apart from certain peptides by using them at different times of day.

Should you use superoxide dismutase in the morning or at night?

You can use superoxide dismutase in the morning or at night, but if you use it with certain peptides like bio-placenta or copper peptides, you should use them at different times of day. Applying superoxide dismutase helps protect your skin from sun damage and oxidative stress.

European Journal of Pharmaceutics and Biopharmaceutics, 2016International Journal of Cosmetic Science, 2004

Can you use superoxide dismutase every day?

Yes, you can use superoxide dismutase every day to help protect your skin against sun damage and reduce irritation. Topical application helps suppress UV-induced redness and sunburn cell formation.

European Journal of Pharmaceutics and Biopharmaceutics, 2016International Journal of Cosmetic Science, 2004

Does superoxide dismutase cause purging or irritation?

Superoxide dismutase is unlikely to cause purging or irritation, as it functions primarily as an antioxidant that helps protect skin against environmental damage. Topical treatment helps soothe the skin and reduce redness or inflammation from UV exposure.

European Journal of Pharmaceutics and Biopharmaceutics, 2016International Journal of Cosmetic Science, 2004

Which skin types is superoxide dismutase best for?

Superoxide dismutase is best for dry skin, sensitive skin, dry sensitive skin, and skin with dark spots with Paula's Choice RESIST Super Antioxidant Concentrate Serum, which Lovi rates as a Superior fit. It also works well for oily skin, combination skin, acne-prone skin, mature skin, and oily acne-prone skin with top-rated options like Paula's Choice RESIST Super Antioxidant Concentrate Serum, Image Skincare Vital C Hydrating Enzyme Masque, and NIOD Modulating Glucosides.

Can you use superoxide dismutase with bio-placenta peptides?

No, you cannot use superoxide dismutase and bio-placenta peptides together because they clash and cancel each other out. Use them at different times of day by applying the peptides in the morning and superoxide dismutase at night.

Research on superoxide dismutase

Behind this ingredient guide

Lovi checks every ingredient with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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