Simple vs Bayer

Questions and answers

Research behind their key ingredients

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation

  Niacinamide · Antioxidants, 2021

• Topical use of dexpanthenol in skin disorders

  Panthenol, Panthenol vitamin b5 · American Journal of Clinical Dermatology, 2002

• Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo

  Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016

• Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

  Azelaic acid · Pharmaceutics, 2021

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy

  Niacinamide · Journal of Cosmetic Dermatology, 2021

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol, Panthenol vitamin b5 · The Journal of Dermatological Treatment, 2017

• Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

  Niacinamide · Scientific Reports, 2024

• Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation

  Tocopheryl acetate vitamin e, Tocopheryl acetate · Urologia Internationalis, 2019

• Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial

  Panthenol, Panthenol vitamin b5, Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020

• High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin

  Witch hazel leaf water · Phytochemistry, 2001

• Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment

  Sodium ascorbyl phosphate · International Journal of Cosmetic Science, 2009

• Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris

  Azelaic acid · Dermatology and Therapy, 2024

• Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial

  Zinc pca · The Journal of Clinical and Aesthetic Dermatology, 2020

• Whitening effect of alpha-bisabolol in Asian women subjects

  Bisabolol · International Journal of Cosmetic Science, 2010

• The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study

  Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023

• Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers

  Sodium ascorbyl phosphate · Drug Research, 2017

• Understanding Solar Skin Elastosis-Cause and Treatment

  Witch hazel leaf water · Journal of Cosmetic Science, 2018

• Borage Oil Treated with Immobilized Lipase Inhibits Melanogenesis

  Borago officinalis seed oil · Lipids, 2020

• Influence of vitamin E acetate on stratum corneum hydration

  Tocopheryl acetate vitamin e, Tocopheryl acetate · Arzneimittel-Forschung, 1998

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol, Panthenol vitamin b5 · Journal of Cosmetic Dermatology, 2025

• Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects

  Sodium ascorbyl phosphate · Experimental Dermatology, 2012

• Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy

  Tocopheryl acetate · Scientific Reports, 2025

• Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial

  Tocopheryl acetate vitamin e, Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021

• Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study

  Sodium laureth sulfate · International Journal of Pharmaceutics, 2026

• A novel facial moisturizer containing Saccharide isomerate accelerates skin barrier restoration following intense pulsed light treatment: a randomized split-face study

  Saccharide isomerate · The Journal of Dermatological Treatment, 2025

• Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial

  Saccharide isomerate · Lasers in Medical Science, 2025

• Saccharide isomerate ameliorates cosmetic scalp conditions in a Chinese study population

  Saccharide isomerate · Journal of Cosmetic Dermatology, 2023

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.