🇪🇸Spain

The INKEY List Niacinamide Serum for mature skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

The INKEY List Niacinamide Serum

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • ExcellentSafety

Works for mature skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Suitable for normal skin, this serum utilizes niacinamide for mild seboregulation and glycerin for humectant action, offering general hydration that can support the appearance of fine lines and wrinkles.
  • Panthenol and allantoin provide soothing benefits, contributing to overall skin comfort and texture improvement.
  • The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of calming components.

How to apply

  • Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
  • Apply this serum after your toner and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • You can apply the serum on dry skin for the best results against fine lines.
  • Always do a patch test before your first use and avoid the sensitive eye area.

People Say

★4.5Overall rating based on 3.5k+ reviews

Based on a very large amount of data, users with oily and blemish-prone skin frequently praise this serum for its ability to regulate sebum production and calm active breakouts without stripping moisture. The majority report clearer skin and reduced redness. A notable minority experience texture issues, such as a sticky finish or white residue if the product is not applied carefully.

Highlights

  • Controls excess oil Often Mentioned
    • “My T-zone was excessively oily... observed a subtle reduction in sebum.”
    • “Helps to control excess oil and keep skin healthy.”
    • “Perfect for oily skin as it helps to reduce sebum.”
    • “Skin is slightly less oily.”
  • Great value & packaging Often Mentioned
    • “Win and a steal at this price.”
    • “Love the fact that it's... affordable.”
    • “I like these bottles... easier to travel with.”
    • “Great budget option that really works.”
  • Reduces redness & blemishes Often Mentioned
    • “Redness has lessened and the cluster of whiteheads... cleared.”
    • “Calms irritated skin and reduces redness.”
    • “Breakouts are far less frequent.”
    • “Helps tame the redness when my skin is a bit sensitized.”
  • Hydrating & lightweight Sometimes Noted
    • “Lightweight and layers easily with skincare.”
    • “Doesn't strip the skin as it is formulated with hyaluronic acid.”
    • “Absorbs quickly... never pills under other skincare.”
    • “Moisturises and hydrates the skin.”
  • Improves skin texture Sometimes Noted
    • “Skin felt smooth, and looked clear and fresh.”
    • “Large pores have shrunk.”
    • “Helped with texture and pore size.”
    • “Smoothed out rough skin.”
  • Sticky or tacky finish Sometimes Noted
    • “Leaves a tackiness that never goes away.”
    • “Slightly tacky and takes time to get absorbed.”
    • “Texture is gelatinous... leaving skin sticky.”
    • “A little bit more on the sticky side compared to The Ordinary.”
  • White residue/crystallization Sometimes Noted
    • “Forms a crust on the hole at the flick top cap.”
    • “Crystallizes on the outlet of the serum bottle.”
    • “Can get a white residue on the skin if not shaken.”
    • “Product can collect at the entrance... dried out/crystallised.”
  • Caused breakouts/irritation Rarely Noted
    • “Had breakouts after using it.”
    • “Gave me a horrendous rash that stung.”
    • “Not so suitable for me... accentuated redness.”
    • “Started reacting negatively to it... after awhile.”
  • Foaming/soaping effect Rarely Noted
    • “Create that foamy whiteness on your face when blending.”
    • “Turns white if you rub it too much.”
    • “Can be sticky if too much is applied.”

Sources: lovi.care, sephora.co.uk, boots.com, cultbeauty.co.uk, lookfantastic.com, theinkeylist.com, and more

Questions and answers

How well does The INKEY List Niacinamide work for mature skin?

This serum works for mature skin, though other products fit it better because it provides general hydration that can support the appearance of fine lines and wrinkles. To better suit mature skin, a product of this type needs potent antioxidants, hydrating components, skin-repairing ingredients, and peptides for optimal moisture retention and skin elasticity.

Journal of Cosmetic Dermatology, 2021Dermatologic Therapy, 2022

Which ingredients make this serum a good fit for mature skin?

This serum fits mature skin through niacinamide, glycerin, squalane, and sodium hyaluronate, which help keep the skin hydrated and support the appearance of fine lines. To fit mature skin even better, a product of this type needs high-concentrate antioxidants, peptides, and skin-repairing ingredients that target signs of aging.

Dermatologic Therapy, 2022Journal of Cosmetic Dermatology, 2021

What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.

Antioxidants, 2021Journal of Cosmetic Dermatology, 2004

What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.

The British Journal of Dermatology, 2008Clinical, Cosmetic and Investigational Dermatology, 2017

Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine, applied after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and avoids extra safety concerns with sun exposure.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum before your retinol product at night. This product helps keep your skin comfortable and hydrated, but mature skin generally benefits more from targeted anti-aging treatments containing peptides, antioxidants, and rich nourishing oils.

How often should I use this serum?

Use this treatment serum in the evening. Mature skin needs products with powerful antioxidants, retinoids, or peptides to deeply firm and smooth lines.

Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or irritation, as reviews show very few complaints about clogged pores and the formula includes calming ingredients. Mature skin generally benefits most from products that combine rich moisturizers like squalane with targeted firming peptides or antioxidants for deeper wrinkle care.

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

    Journal of Cosmetic Dermatology, 2021

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

    Scientific Reports, 2024

  • A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

    The Journal of Dermatological Treatment, 2017

  • Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

    Dermatologic Therapy, 2022

  • Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

    The Journal of Investigative Dermatology, 2008

  • Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

    Dermatologic Surgery, 2005

  • Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

    Journal of Cosmetic and Laser Therapy, 2006

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

    Molecules, 2025

  • Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

    Antioxidants, 2025

  • Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

    Journal of Drugs in Dermatology, 2011

  • Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

    Clinical Oral Investigations, 2022

  • Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

    BMC Oral Health, 2019

Why other serums fit mature skin better

Ingredients

Water, Niacinamide, Glycerin, Propanediol, Butylene Glycol, Phenoxyethanol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Hydroxyethylcellulose, Squalane, Xanthan Gum, Glycine Soja Oil Soybean Oil, Allantoin, Sodium Phytate, Polysorbate 60, Panthenol, Glycolipids, Leuconostoc Radish Root Ferment Filtrate, Sorbitan Isostearate, Glycine Soja Soybean Sterols, Citric Acid, Sodium Hyaluronate, Disodium Phosphate, Sodium Phosphate

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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Prices checked 5 Nov 2026

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

How does it fit your skin?

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