ISDIN Retinal Intense Serum for dry skin
Retinaldehyde
Niacinamide
Bakuchiol
Tocopherol
Palmitoyl Tetrapeptide-7
Low
- AverageDry Skin Fit
- HighEffectiveness
- ConcerningSafety
A weak match for dry skin; the serums alongside fit it better.
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your dry or flaky skin due to the presence of niacinamide and bakuchiol, which provide hydration and gentle exfoliation.
- The inclusion of glycerin offers humectant action, but the formula lacks sufficient emollient ingredients like Dimethicone and Dibutyl Adipate to fully address your dryness.
How to apply
- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.8Overall rating based on 100+ reviewsBased on limited data, users highly praise this biphasic night serum for its ability to smooth skin texture and soften fine lines, with many noting it's gentle and non-irritating, even for sensitive skin. While most users experience positive anti-aging results and appreciate its elegant texture, some find the price point to be high and a few report a short shelf life or slow results for deeper wrinkles.
Highlights
Gentle & non-irritating Often Mentioned
- “no excessive exfoliation”
- “gentle enough for sensitive skin”
- “hydrating and calming”
Smoother skin texture Often Mentioned
- “skin was much smoother”
- “leaves an incredibly soft feeling”
- “smoother, toned complexion”
Elegant texture Sometimes Noted
- “silky-smooth finish”
- “absorbs well”
- “luxurious feel”
Visible anti-aging Sometimes Noted
- “softening fine lines”
- “visible difference in 58-year-old skin”
- “reduces wrinkles”
High price point Sometimes Noted
- “hefty price tag”
- “expensive”
- “un poco caro (a bit expensive)”
Initial mild irritation Rarely Noted
- “slight peeling”
- “sensation of heat”
- “minor redness initially”
Short shelf life Rarely Noted
- “only good within 3 months”
- “hard to finish in time”
- “short expiration after opening”
Slow results for some Rarely Noted
- “no noticeable changes yet”
- “limited effect on blemishes”
- “takes time to work”
Sources: lovi.care, lovelyskin.com, dermstore.com, lyskin.com, clinikally.com, youtube.com, and more
Questions and answers
Why is ISDIN Retinal Intense a weak match for dry skin?
ISDIN Retinal Intense Serum is a weak match because, although it offers some hydration and gentle exfoliation from niacinamide, bakuchiol, and glycerin, it lacks enough heavy softening ingredients to fully address dry skin. A product of this type needs rich hydrating ingredients like ceramides, propolis, or bifida ferment, along with soothing agents, to properly nourish and support dry skin without irritation.
Which ingredients make this serum a poor fit for dry skin?
This serum is a weak match for dry skin because it lacks enough softening and smoothing ingredients to fully address dryness. A product of this type needs rich moisturizing ingredients like ceramides, nourishing plant oils, and extra glycerin to properly hydrate dry skin.
What does Retinal do for dry skin?
Retinal helps smooth dry skin and is unlikely to cause severe dryness when used properly, though it may occasionally lead to mild scaling or irritation as the skin adjusts. This ingredient works best when paired with gentle moisturizers to keep the face feeling soft and comfortable.
What does Niacinamide do for dry skin?
Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Journal of Cosmetic Dermatology, 2004Journal of Cosmetic Dermatology, 2026
Where does this serum go in a skincare routine for dry skin?
This treatment goes in the evening routine after cleansing and before your moisturizer. Dry skin needs a serum with rich moisturizing oils and rich skin-softening ingredients to fully tackle flakiness and keep the skin smooth.
Can I use this serum with AHA, and in what order?
You should use this serum at night and apply your AHA on a different night to help prevent dryness and irritation. This product needs richer nourishing ingredients and extra softening hydrators to properly care for dry skin.
How often should I use this serum?
This serum is a weak match for dry skin and needs extra rich, softening ingredients and soothing hydrators to fully address your dryness. You can use it in your evening routine, starting just once a week and slowly increasing the frequency only if your skin tolerates it well.
Can this serum clog pores, cause breakouts or purging for dry skin?
This serum is unlikely to clog pores or cause breakouts on dry skin, but it may cause initial mild irritation as your skin adjusts to the retinaldehyde. To properly care for dry skin, this type of product needs extra rich smoothing and softening ingredients alongside hydrating components.
Is this serum fragrance-free and alcohol-free?
It contains fragrance (parfum) and drying alcohol (alcohol denat).
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index.
Journal of Cosmetic Dermatology, 2018Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance.
Dermatology, 2002Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients.
Dermatology, 1999Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.
Clinical, Cosmetic and Investigational Dermatology, 2015Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.
Health Science Reports, 2025Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo.
Journal of Cosmetic Dermatology, 2015Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components.
International Journal of Cosmetic Science, 2026
Why other serums fit dry skin better
Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019
Ingredients
Water, Dimethicone, Dibutyl Adipate, Niacinamide, Isoamyl Laurate, Lauryl Peg Ppg-18 18 Methicone, Glycerin, Propanediol, Dimethicone Vinyl Dimethicone Crosspolymer, Alcohol Denat, Bakuchiol, 2-Hexanediol, Pentylene Glycol, Caprylic Capric Triglyceride, Ethylcellulose, Hydroxyacetophenone, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-T-Butylcyclohexanol, Caprylyl Glycol, Parfum, Sodium Acrylates Crosspolymer-2, Polyacrylate Crosspolymer-6, Vigna Aconitifolia Seed Extract, Tocopheryl Acetate, Tocopherol, Citric Acid, Xanthan Gum, Maltodextrin, Melatonin, Retinal Retinaldehyde, Silica, Disodium Edta, Synthetic Fluorphlogopite, Ci 77891 Titanium Dioxide, Ascorbic Acid, T-Butyl Alcohol, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Palmitoyl Tetrapeptide-7, Tin Oxide, Chrysin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
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Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
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Dermatology and diagnostic consultant
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Victoria Derkova, MS
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Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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