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Avène Cleanance Comedomed Anti-Blemish Concentrate for combination skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Avène Cleanance Comedomed Anti-Blemish Concentrate

Low

  • SuperiorCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

A weak match for combination skin; the serums alongside fit it better.

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate blemish reduction for your acne-prone skin due to silybum marianum fruit extract, while isopropyl alcohol helps regulate sebum for your combination skin.
  • While the formula provides general skincare benefits like hydration and cleansing, it lacks specialized ingredients to directly address your oily shine concerns.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients.

How to apply

  • Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
  • Apply the serum after cleansing and toner, and right before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
  • Apply the serum on clean and dry skin since your skin is not sensitive.
  • Always do a patch test before using the serum for the first time, and avoid the eye area .

People Say

★4.3Overall rating based on 4.0k+ reviews

Based on a very large amount of data, this concentrate is highly effective for oily and acne-prone skin, significantly reducing active breakouts and preventing future blemishes. Users frequently praise its lightweight, fast-absorbing, and mattifying texture. A strong alcohol scent is commonly noted, and some users experience initial dryness or purging.

Highlights

  • Lightweight & fast-absorbing Mostly Mentioned
    • “absorbs super fast”
    • “watery gel texture”
    • “non-greasy finish”
    • “leaves skin matte”
  • Reduces blemishes Mostly Mentioned
    • “significant reduction in blemishes”
    • “keeps whiteheads at bay”
    • “cleared my hormonal acne”
    • “pores look smaller”
  • Strong alcohol scent Mostly Mentioned
    • “powerful alcohol smell”
    • “smells like hand sanitizer”
    • “strong chemical odor”
    • “scent is overpowering”
  • Controls oil Often Mentioned
    • “mattifies the skin”
    • “controls excess sebum”
    • “less oily during the day”
    • “shine-free complexion”
  • Prevents breakouts Sometimes Noted
    • “limits recurrence of spots”
    • “stops pimples forming”
    • “prevented PMS breakouts”
    • “keeps skin clear long-term”
  • Drying or peeling Sometimes Noted
    • “made my face peel”
    • “caused dry patches”
    • “drying around the nose”
    • “not moisturizing enough alone”
  • Initial skin purging Rarely Noted
    • “sped up the purge”
    • “broke out more at first”
    • “worsened acne before improving”
    • “caused small bumps initially”
  • Stinging sensation Rarely Noted
    • “slight burning upon application”
    • “stings sensitive areas”
    • “tingling sensation”
    • “irritated broken skin”

Sources: lovi.care, dermstore.com, aveneusa.com, beautycrew.com.au, hometesterclub.com, reddit.com, and more

Questions and answers

Why is Avène Cleanance Comedomed a weak match for combination skin?

This treatment is a weak match because it lacks specialized ingredients to directly address your oily shine concerns. A product of this type needs effective ingredients like niacinamide, zinc PCA, or propolis to provide significant benefits for managing oily shine and regulating oiliness without any risk of irritation or unsuitability for combination skin.

Which ingredients make this treatment a poor fit for combination skin?

This treatment is a weak match for your combination skin because it lacks specialized ingredients like niacinamide, zinc PCA, or propolis to directly address your oily shine concerns. A better fit for this skin type needs balancing and oil-regulating ingredients that provide adequate hydration without overwhelming oilier areas.

What does Avène Thermal Spring Water do for combination skin?

Avène Thermal Spring Water helps calm redness and keeps combination skin comfortable by soothing sensitive areas. It is unlikely to cause irritation and supports overall skin balance.

Journal of the European Academy of Dermatology and Venereology, 2020Journal of the European Academy of Dermatology and Venereology, 2011

What does Milk Thistle Fruit Extract do for combination skin?

Milk thistle fruit extract helps keep combination skin calm and balanced by providing gentle antioxidant and soothing care that supports the skin barrier. This ingredient is unlikely to cause irritation and may help improve hydration while managing oily spots nicely.

Journal of Personalized Medicine, 2022Journal of Cosmetic Dermatology, 2025

Where does this treatment go in a skincare routine for combination skin?

This treatment goes in the evening routine for combination skin. To properly care for combination skin, a product of this type needs specialized ingredients that directly address oily shine.

Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first, waiting for it to absorb, and then applying this treatment, or by using them on alternate nights to prevent dryness and irritation. When combining active treatments, starting slowly helps your skin adjust safely.

How often should I use this treatment?

You can use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. A product of this type for your combination skin needs extra oil-controlling and mattifying ingredients to properly address your oily shine concerns.

Can this treatment clog pores, cause breakouts or purging for combination skin?

This treatment is unlikely to cause clogged pores, but it may cause initial skin purging when you first start using it. While it is generally safe, the formula contains alcohol which can be drying for combination skin.

Is this treatment fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (isopropyl alcohol).

What the research says

  • Balneotherapy with thermal water altered specific skin microbiota at genus and species levels in healthy female volunteers compared to tap water, which produced no significant microbiome changes.

    Life, 2023

  • Malaysian thermal spring water as an adjunct to standard acne therapy improved skin hydration, reduced dryness and stinging, enhanced overall tolerability, and improved the acne disability index in patients with mild to moderate acne.

    The Medical Journal of Malaysia, 2024

  • A 2% Sphingomonas xenophaga ferment extract cream applied twice daily for 4 weeks significantly decreased facial vascular disorder scores compared to vehicle in 86 Caucasian female subjects, alongside dose-dependent inhibition of pre-kallikrein activity in vitro.

    International Journal of Cosmetic Science, 2025

  • Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group.

    Journal of Cosmetic Dermatology, 2024

  • Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events.

    Journal of Cosmetic Dermatology, 2023

  • Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris.

    Journal of Cutaneous Medicine and Surgery, 2024

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • The use of 70% isopropyl alcohol in conjunction with scrubbing with a bristled brush significantly reduced positive bacterial cultures at the nail fold compared to povidone-iodine with soft sponges in volunteers.

    The Journal of Bone and Joint Surgery. American Volume, 2005

  • Friction with 70% ethyl or isopropyl alcohol immediately eliminates the heart-shaped pigmented lesion characteristic of terra firma-forme dermatosis in a 14-year-old boy.

    Cureus, 2024

  • Rubbing 70% isopropyl alcohol wipes cleared persistent reticulated brown patches in five patients with terra firma-forme dermatosis.

    Skinmed, 2016

  • A functional cosmetic cream containing bioactive materials from Streptomyces sp. T65 embedded in SBA-15 decreased skin roughness by 4.670% and increased skin brightness by 0.472% after 4 weeks of application, while demonstrating antimicrobial, antioxidant, anti-aging, and whitening activities.

    Antioxidants, 2020

  • Film-forming formulations containing porous silica achieved skin permeation rates comparable to immediate release formulations while confirming prolonged drug availability and causing no skin irritation in healthy volunteers.

    European Journal of Pharmaceutical Sciences, 2017

  • Topical treatment with silica mud and microalgae extracts from the Blue Lagoon improved skin barrier function by inducing epidermal gene expression and reducing transepidermal water loss in healthy humans, while preventing skin aging markers in vitro.

    Experimental Dermatology, 2008

Why other serums fit combination skin better

  • Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.

    BioMed Research International, 2022

  • A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

    Journal of Cosmetic Dermatology, 2024

Ingredients

Avène Thermal Spring Water Avène Aqua, Isopropyl Alcohol, Peg-6, Glycerin, Silybum Marianum Fruit Extract, Silica, Polyacrylate-13, Polyisobutene, Polysorbate 20, Sorbitan Isostearate, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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