Estée Lauder Perfectly Clean Multi-Action Toning Lotion/Refiner for sensitive skin

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Questions and answers

What the research says

• Lactobionic acid produced better skin performance with a lack of skin irritation and barrier impairment compared to glycolic acid in 77 healthy volunteers.

  Journal of Cosmetic Dermatology, 2010

• Combining a 20% lactobionic acid peel with aluminum oxide crystal microdermabrasion increases skin hydration, improves elasticity, and decreases transepidermal water loss in 20 Caucasian females compared to lactobionic acid peel alone.

  Journal of Cosmetic Dermatology, 2019

• Hamamelis bark proanthocyanidins strongly increased the proliferation of cultured human keratinocytes and reduced transepidermal water loss and erythema formation in SLS-irritated skin, whereas the polysaccharide fraction had no effect.

  Phytochemistry, 2001

• An emulsion containing 10% lactobionic acid significantly reduces human skin surface pH without causing skin irritation or barrier impairment.

  Journal of Cosmetic Dermatology, 2019

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Carboxytherapy alone and combined with lactobionic acid, ferulic acid, and ascorbic acid significantly reduced vascular dark circles and combined pigmentation in the tear trough and lower eyelid of 39 Caucasian participants.

  Clinical, Cosmetic and Investigational Dermatology, 2024

• Lactobionic acid improved skin barrier function most compared to other AHAs and BHAs when tested on an ex vivo porcine skin model, confirming significant barrier-protective effects and enabling toxicity evaluation of cosmetic ingredients.

  International Journal of Molecular Sciences, 2021

• Lactobionic acid per se and incorporated into an alkyl polyglucoside-based emulsion demonstrated satisfying antioxidant and moisturizing efficacy.

  International Journal of Cosmetic Science, 2012

• A Hamamelis virginiana leaf extract increased LOXL1 expression twofold, decreased elafin synthesis, restored functional elastic fibers, reduced nonfunctional elastin aggregates, decreased wrinkles, and improved skin firmness.

  Journal of Cosmetic Science, 2018

• Witch hazel bark extract and hamamelitannin showed pronounced anti-inflammatory activity, supported keratinocyte migration in a wound healing assay, and inhibited Staphylococcus aureus growth, whereas their skin microbiota metabolite ellagic acid stimulated inflammatory mediator release.

  Journal of Ethnopharmacology, 2025

• Hamamelis virginiana bark extract inhibited Cutibacterium acnes-induced IL-6 release and TNF-α-induced IL-8 release in human keratinocytes without showing antibacterial or antibiofilm activities.

  Antioxidants, 2022

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Ethyl acetate and aqueous fractions of Bambusa vulgaris leaves accelerate cutaneous wound healing and inhibit carrageenan-induced paw edema in rats.

  Journal of Ayurveda and Integrative Medicine, 2016

Ingredients

Water, Alcohol Denat, Glycerin, Butylene Glycol, Hypnea Musciformis Extract Algae Extract, Gellidiela Acerosa Extract Algae Extract, Witch Hazel, Silybum Marianum Extract, Bambusa Vulgaris Extract, Pisum Sativum Extract, Gentiana Lutea Root Extract, Algae Extract, Rice Bran Extract, Yeast Extract, Sucrose, Trehalose, Lactobionic Acid, Peg-40 Hydrogenated Castor Oil, Sorbitol, Caffeine, Dipotassium Glycyrrhizate, Biosaccharide 1 Gum, Ppg-26-Buteth-26, Sodium Hyaluronate, Zinc Pca, Pentylene Glycol, Ppg-5-Ceteth-20, Sodium Hydroxide, Glucosamine Hcl, Parfum, Phytic Acid, Potassium Sorbate, Disodium Edta, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.