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Vitamin C and acetyl hexapeptide-3

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Vitamin C and acetyl hexapeptide-3: depends on the strength

Depends on the strength

Apply vitamin C in the morning and acetyl hexapeptide-3 at night, because combining them in the same routine makes them less effective. Vitamin C helps brighten skin, while acetyl hexapeptide-3 helps smooth fine lines. You can use both products safely by keeping them in separate daily routines.

Microneedle-Mediated Delivery of Copper Peptide Through Skin

Vitamin C products

Acetyl hexapeptide-3 products

Questions and answers

Can you use vitamin C and acetyl hexapeptide-3 together?

Using vitamin C and acetyl hexapeptide-3 together depends on the strength of the products, such as in La Mer The Serum Essence or Origins Original Skin Renewal Serum. You may need to use them in separate routines to avoid reducing peptide efficacy, as copper and peptides can interact negatively with vitamin C.

Which goes first, vitamin C or acetyl hexapeptide-3?

You should use vitamin C and acetyl hexapeptide-3 in separate routines because mixing copper and peptides with vitamin C may reduce peptide efficacy and oxidize the vitamin.

Are vitamin C and acetyl hexapeptide-3 good for sensitive skin?

Whether vitamin C and acetyl hexapeptide-3 work well together depends on the strength and specific product, as pure L-ascorbic acid and copper peptides should generally be separated to avoid reducing peptide efficacy. Products like La Mer The Serum Essence, Origins Original Skin Renewal Serum, and Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10% combine these ingredients, though sensitive skin types may prefer using them in separate routines.

Research on vitamin C and acetyl hexapeptide-3

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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