Acetyl hexapeptide-3 and GABA

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Work well together

Use them together, applying the peptide first and GABA second, for better skin firmness and hydration. The amino acid derivative helps the peptide work more effectively to smooth expression lines. You can use a lower strength or wait a few minutes between layers if your skin feels sensitive.

Acetyl hexapeptide-3 products

The Ordinary Multi-Peptide + Copper Peptides 1% Serum £28.90
The Ordinary Multi-Peptide + HA Serum £12.72
Medik8 Liquid Peptides £51.15
La Mer The Treatment Lotion £209.56
Rhode Peptide Glazing Fluid £35.00
The Ordinary Argireline Solution 10% £7.36
Good Molecules Super Peptide Serum £17.00
Clinique Smart Clinical Repair Wrinkle Correcting Serum £46.87
La Mer The Renewal Oil £175.50
Estée Lauder Micro Essence Treatment Lotion £42.00
The INKEY List Collagen Peptide Serum
La Mer The Eye Concentrate £199.00

GABA products

Revision Skincare Revox™ Line Relaxer

Questions and answers

Can you use acetyl hexapeptide-3 and GABA together?

Yes, acetyl hexapeptide-3 and GABA work well together to support structural protein synthesis and moisture balance, and you can use them in hydrating and reparative complexes.

Which goes first, acetyl hexapeptide-3 or GABA?

Acetyl hexapeptide-3 and GABA work well together to support moisture balance and structural proteins. You can use them together as part of your regular skincare routine.

Are acetyl hexapeptide-3 and GABA good for sensitive skin?

Acetyl hexapeptide-3 and GABA work well together because amino acids and NMF components support structural protein synthesis and moisture balance, and Lovi rates their fit as High for all skin types.

Research on acetyl hexapeptide-3 and GABA

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-3 · Annals of Dermatology, 2019
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

Nadia Kapleva, MS

Co-founder, Medical Director

Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD

Co-founder, CEO and CTO

PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc

Medical Board

Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD

Medical Board

Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS

Medical Board

Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD

Medical Board, Medical Advisor

Dermatology MD
Elina Nazarenko, MD

Medical Board

Dermatology and diagnostic consultant
Victoria Derkova, MS

Medical Board

Cosmetic chemist, cosmetic development technologist

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