Acetyl hexapeptide-3 and polyvinyl alcohol

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes · How the Fit score works

Keep them apart

Use them at different times of day, applying the peptide first and the alcohol product later. Harsh alcohols can break down your anti-aging peptides before they have a chance to smooth your skin. You can switch to a lower alcohol percentage or space them out by several hours.

Acetyl hexapeptide-3 products

The Ordinary Multi-Peptide + Copper Peptides 1% Serum £28.90
The Ordinary Multi-Peptide + HA Serum £12.72
Medik8 Liquid Peptides £51.15
La Mer The Treatment Lotion £209.56
Rhode Peptide Glazing Fluid £35.00
The Ordinary Argireline Solution 10% £7.36
Good Molecules Super Peptide Serum £17.00
Clinique Smart Clinical Repair Wrinkle Correcting Serum £46.87
La Mer The Renewal Oil £175.50
Estée Lauder Micro Essence Treatment Lotion £42.00
The INKEY List Collagen Peptide Serum
La Mer The Eye Concentrate £199.00

Polyvinyl alcohol products

Olay Cleansing Melts

Questions and answers

Can you use acetyl hexapeptide-3 and polyvinyl alcohol together?

Keep acetyl hexapeptide-3 and polyvinyl alcohol apart because strong surfactants and alcohols can denature the peptide structure and reduce its effectiveness. If you wish to use both, apply them in separate routines.

Which goes first, acetyl hexapeptide-3 or polyvinyl alcohol?

Keep acetyl hexapeptide-3 and polyvinyl alcohol apart in your routine. Combining them may break down the peptide and reduce how well it works.

Are acetyl hexapeptide-3 and polyvinyl alcohol good for sensitive skin?

No, you should keep acetyl hexapeptide-3 and polyvinyl alcohol apart because strong alcohols can denature the peptide and reduce how well it works, which is particularly risky for dry, sensitive skin.

Research on acetyl hexapeptide-3 and polyvinyl alcohol

The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study
Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin
Acetyl hexapeptide-3 · Annals of Dermatology, 2019
The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study
Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects
Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

Nadia Kapleva, MS

Co-founder, Medical Director

Cosmetic chemist, cosmetologist, aesthetic products developer
Alexey Shagraev, PhD

Co-founder, CEO and CTO

PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
Dr. Sofía Perea Pérez, MD, MSc

Medical Board

Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
Aishani Shah, MD

Medical Board

Specialist dermatologist, MBBS, MD, IFAAD
Asya Zubkova, MS

Medical Board

Cosmetic chemist, SCS, IFSCC member
Hanna Kurets, MD

Medical Board, Medical Advisor

Dermatology MD
Elina Nazarenko, MD

Medical Board

Dermatology and diagnostic consultant
Victoria Derkova, MS

Medical Board

Cosmetic chemist, cosmetic development technologist

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