Acetyl hexapeptide-3 and potassium hydroxide
Keep them apart
Use them at different times of day, applying acetyl hexapeptide-3 first and potassium hydroxide later, because they clash in acidity. The strong alkalinity breaks down the peptide, making it completely useless on your skin. You can space them out into separate routines or switch to a gentler product.
Acetyl hexapeptide-3 products
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The Ordinary
Multi-Peptide + Copper Peptides 1% Serum
拢28.90
-
The Ordinary
Multi-Peptide + HA Serum
拢12.72
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Medik8
Liquid Peptides
拢51.15
-
La Mer
The Treatment Lotion
拢209.56
-
Rhode
Peptide Glazing Fluid
拢35.00
-
The Ordinary
Argireline Solution 10%
拢7.36
-
Good Molecules
Super Peptide Serum
拢17.00
-
Clinique
Smart Clinical Repair Wrinkle Correcting Serum
拢46.87
-
La Mer
The Renewal Oil
拢175.50
-
Est茅e Lauder
Micro Essence Treatment Lotion
拢42.00
- The INKEY List Collagen Peptide Serum
-
La Mer
The Eye Concentrate
拢199.00
Potassium hydroxide products
- Glytone Mild Gel Cleanser
Questions and answers
Can you use acetyl hexapeptide-3 and potassium hydroxide together?
Keep acetyl hexapeptide-3 and potassium hydroxide apart because mixing peptides with highly alkaline environments causes them to lose stability and activity. Acetyl hexapeptide-3 applied twice daily for 4 weeks helps reduce wrinkles and skin roughness.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Which goes first, acetyl hexapeptide-3 or potassium hydroxide?
Keep acetyl hexapeptide-3 and potassium hydroxide apart because alkaline environments destabilize peptides. Use them in separate routines to maintain peptide effectiveness.
Are acetyl hexapeptide-3 and potassium hydroxide good for sensitive skin?
Acetyl hexapeptide-3 and potassium hydroxide should be kept apart because highly alkaline environments cause peptides to lose stability and activity. Acetyl hexapeptide-3 applied twice daily for four weeks helps decrease skin roughness and provides anti-wrinkle effects.
American Journal of Clinical Dermatology, 2013Journal of Cosmetic and Laser Therapy, 2013
Research on acetyl hexapeptide-3 and potassium hydroxide
Behind this pairing advice
Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
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Co-founder, CEO and CTO
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Dr. Sof铆a Perea P茅rez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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